Glycemic and Weight Loss Effects of Semaglutide in People with Spinal Cord Injury and Type 2 Diabetes

Who could benefit from this research

What this research studies

People with spinal cord injury often develop diabetes younger and more severely, with added risks from obesity and autonomic problems. The study will look at how semaglutide, a GLP-1 receptor agonist, affects blood glucose tolerance, weight, and related metabolic factors in SCI patients with type 2 diabetes. Researchers will monitor safety, tolerability, and changes in pancreatic beta-cell function to understand potential benefits for this high-risk group. The trial builds on existing data showing GLP-1RAs improve glucose and weight in the general population but are underused in SCI patients. If successful, this work could guide personalized diabetes management for people living with SCI.

Why it matters

Where this research is happening

• University of Texas Hlth Science Center
  San Antonio, United States Active

Researchers

• Principal investigator: Salehi, Marzieh — University of Texas Hlth Science Center
• Study coordinator: Salehi, Marzieh

Related research

Other NIH-funded projects on the same topics.

• Effects of Semaglutide on Diabetes and Weight Loss in People with Spinal Cord Injury

  This study is looking at how well semaglutide, a medication that helps with blood sugar control and weight loss, works for people with spinal cord injuries who also have type 2 diabetes, to see if it can help them manage their diabetes better.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11179324

• Subtyping Core for Research on the Causes of Type 2 Diabetes (SCORE-T2D)

  A new U01 grant from a university research team aims to understand why Type 2 diabetes differs so much between people and how to tailor prevention and treatment.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11617648

• Michigan Diabetes Project: A Peer-Led Self-Management Program for Adults with Type 2 Diabetes

  A peer-led self-management program for adults with type 2 diabetes is being tested to see if it improves blood sugar control and daily diabetes care.

  NIH research Kaiser Foundation Research Institute · Oakland, UNITED STATES · NIH-11594416

• Alzheimer’s and dementia risk in people with prediabetes or type 2 diabetes

  This grant aims to understand why some older adults with prediabetes or type 2 diabetes develop memory problems or dementia.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11585476

• Personalized use of newer diabetes medicines for Type 2 diabetes

  Aiming to tailor use of newer glucose-lowering drugs for people with type 2 diabetes to improve health and access in real-world settings.

  NIH research Purdue University · West Lafayette, United States · NIH-11571362

• Alzheimer’s and related dementia in older adults with prediabetes or type 2 diabetes

  This grant aims to understand why cognitive problems occur in people 65 and older who have prediabetes or type 2 diabetes, using data from a long-running diabetes study to identify what drives memory and thinking decline.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11537840

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.