Understanding Why Weight Comes Back After Losing It
Predicting Weight Regain Following Weight Loss Using Physiological Measures of Appetite and Energy Expenditure
This project aims to understand why people regain weight after successfully losing it, by looking at how their body's appetite and metabolism change.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Drexel University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11334136 on NIH RePORTER |
What this research studies
Many people struggle to keep weight off after losing it, and this project wants to find out why. We will recruit 100 individuals for a weight loss program and carefully measure changes in their body's energy use and how their brain responds to food. By tracking these changes, we hope to identify specific physical signals that can predict who might regain weight. This information could help us develop better strategies to maintain weight loss in the future.
Who could benefit from this research
Good fit: Ideal candidates are individuals interested in participating in a weight loss program who are willing to undergo physiological assessments.
Not a fit: Patients not interested in a structured weight loss program or who are not able to commit to follow-up assessments may not receive direct benefit from this particular opportunity.
Why it matters
Potential benefit: If successful, this work could lead to new ways to predict and prevent weight regain, helping individuals maintain their weight loss long-term.
How similar studies have performed: While behavioral weight loss programs are common, understanding the specific physiological predictors of weight regain is an ongoing area of active investigation.
Where this research is happening
Philadelphia, United States
- Drexel University — Philadelphia, United States (Active)
Researchers
- Principal investigator: Lowe, Michael R — Drexel University
- Study coordinator: Lowe, Michael R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.