Does giving IV fluids to mothers before birth change how much a newborn loses weight in the first days?
Impact of Prepartum Intravenous Fluid Intake on Newborn Weight Loss in the First Days of Life
This project sees if the amount of IV fluids a mother receives before delivery affects weight loss in formula-fed newborns during their first two days of life.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | Female |
| Sponsor | Centre Hospitalier Universitaire, Amiens Academic / other |
| Locations | 1 site (Amiens, Picardie) |
| Trial ID | NCT07243054 on ClinicalTrials.gov |
What this trial studies
This is a retrospective, observational single-center review using medical records from CHU Amiens to explore links between maternal prepartum intravenous fluid administration during labor and early neonatal weight changes. The analysis included mothers aged 18 and older with full-term (≥37 weeks), singleton deliveries whose infants were exclusively formula-fed in the maternity ward, with daily newborn weights recorded for the first two days. Records with incomplete data, mixed or exclusive breastfeeding, maternal hemodynamic disorders requiring targeted filling, or infants with renal/uropathy or cleft conditions were excluded. Investigators compared maternal fluid volumes given before delivery with newborn weight loss and early signs such as jaundice or respiratory distress.
Who should consider this trial
Good fit: Ideal candidates are mothers aged 18 or older who delivered a full-term singleton at CHU Amiens and whose infants were exclusively formula-fed in the maternity ward for the first two days.
Not a fit: Patients who are breastfeeding, had preterm or multiple births, required maternal hemodynamic support before delivery, or whose infants have renal disease or cleft conditions are unlikely to benefit from these specific findings.
Why it matters
Potential benefit: If a clear link is found, clinicians could adjust pre-delivery IV fluid practices or newborn assessment timing to reduce misleading early weight loss and related complications like jaundice.
How similar studies have performed: Previous observational work has suggested maternal intrapartum IV fluids can transiently affect neonatal weight change, but results are mixed and the effect remains incompletely settled.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Full-term delivery (≥37+0 SA) * Singleton pregnancy * Mother over 18 years of age * Infant formula feeding exclusively in the maternity ward for the first 2 days Exclusion Criteria: * Mother under guardianship * Mother who does not understand French * Mother objecting to her personal data being reused for research purposes * Incomplete or incorrectly completed patient medical record * Mixed or exclusive breastfeeding * Mother presenting a hemodynamic disorder in the 12 hours preceding delivery, requiring a filling specifically for this reason * Child with renal pathology or uropathy * Children with cleft lip, palate or labio-palate
Where this trial is running
Amiens, Picardie
- CHU Amiens Picardie — Amiens, Picardie, France (Recruiting)
Study contacts
- Study coordinator: Pierre Tourneux, Pr
- Email: Tourneux.Pierre@chu-amiens.fr
- Phone: 33+3 22 08 76 04
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.