Improving brain barrier function in patients with type 2 diabetes
Type 2 Diabetes Mellitus and Blood Brain Barrier Function Improvement- A Randomized Clinical Trial
['FUNDING_R21'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-11074062
This study is looking at ways to help improve brain health in adults with type 2 diabetes by checking how well the blood-brain barrier is working and seeing if taking thiamine can make it better, which could help with thinking and mood.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11074062 on ClinicalTrials.gov |
What this research studies
This research investigates how to improve the function of the blood-brain barrier in adults with type 2 diabetes mellitus (T2DM), which is often linked to cognitive and mood deficits. The study will utilize non-invasive MRI techniques to assess the blood-brain barrier's status and explore whether interventions, such as thiamine supplementation, can repair its function. By focusing on these improvements, the research aims to enhance cognitive health and reduce the risk of dementia in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have been diagnosed with type 2 diabetes mellitus.
Not a fit: Patients who do not have type 2 diabetes or those with other forms of diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cognitive function and quality of life for patients with type 2 diabetes.
How similar studies have performed: Previous studies have shown promise in repairing blood-brain barrier function in diabetes, suggesting that this approach may be effective.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KUMAR, RAJESH — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: KUMAR, RAJESH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: adult onset diabetes, Adult-Onset Diabetes Mellitus, Alzheimer disease dementia