NIH-funded research R21 grant

Exploring new muscle chemistry in adults with Type 2 diabetes

Official title: Elucidating Skeletal Muscle Novel Molecular Mechanisms of Type 2 Diabetes Mellitus

Funded at Ut Southwestern Medical Center · NIH-11454003 · Data updated 2026-11-12

A study will test a new imaging method to measure muscle metabolites in adults with Type 2 diabetes to better understand how the disease affects their muscles.

More Diabetes research and trials

Quick facts

Grant typeR21 grant
Study typeNIH-funded research
Funding institutionUt Southwestern Medical Center
NIH-funded
Lab location1 site (Dallas, United States)
Project startSeptember 1, 2026
Project endAugust 31, 2028
Funding year2026
Award (this year)$221,387
NIH project number1R21EB038528-01A1
Project IDNIH-11454003 on NIH RePORTER

Who could benefit from this research

Could help

Adults with Type 2 diabetes who can undergo the imaging procedure.

Less likely to help

Individuals without Type 2 diabetes or those unable to complete the imaging protocol may not benefit.

What this research studies

If you have Type 2 diabetes, this project will use an advanced MRI-like technique to look at how muscles in the legs process fats and sugars. The goal is to map key molecules in muscle tissue over a short scan, so doctors can see how diabetes changes muscle health without invasive procedures. This information could guide future treatments that slow diabetes progression and reduce side effects. Participants would undergo a clinically feasible imaging session and may contribute to a better understanding of muscle metabolism in diabetes.

Why it matters

Potential benefit: If successful, the research could lead to non-invasive ways to monitor and tailor treatments that improve muscle metabolism in people with Type 2 diabetes.

How similar studies have gone: Previous work shows metabolites in muscle relate to insulin resistance, but this study tests a novel imaging approach.

Where this research is happening

  • Ut Southwestern Medical Center
    Dallas, United States
    Active

Researchers

  • Principal investigator: Sarma, Manoj Kumar — Ut Southwestern Medical Center
  • Study coordinator: Sarma, Manoj Kumar

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.