Exploring new muscle chemistry in adults with Type 2 diabetes
Official title: Elucidating Skeletal Muscle Novel Molecular Mechanisms of Type 2 Diabetes Mellitus
Funded at Ut Southwestern Medical Center · NIH-11454003 · Data updated 2026-11-12
A study will test a new imaging method to measure muscle metabolites in adults with Type 2 diabetes to better understand how the disease affects their muscles.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $221,387 |
| NIH project number | 1R21EB038528-01A1 |
| Project ID | NIH-11454003 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with Type 2 diabetes who can undergo the imaging procedure.
✕Less likely to help
Individuals without Type 2 diabetes or those unable to complete the imaging protocol may not benefit.
What this research studies
If you have Type 2 diabetes, this project will use an advanced MRI-like technique to look at how muscles in the legs process fats and sugars. The goal is to map key molecules in muscle tissue over a short scan, so doctors can see how diabetes changes muscle health without invasive procedures. This information could guide future treatments that slow diabetes progression and reduce side effects. Participants would undergo a clinically feasible imaging session and may contribute to a better understanding of muscle metabolism in diabetes.
Why it matters
Potential benefit: If successful, the research could lead to non-invasive ways to monitor and tailor treatments that improve muscle metabolism in people with Type 2 diabetes.
How similar studies have gone: Previous work shows metabolites in muscle relate to insulin resistance, but this study tests a novel imaging approach.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Sarma, Manoj Kumar — Ut Southwestern Medical Center
- Study coordinator: Sarma, Manoj Kumar
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.