Condition

Arterial Hypertension clinical trials and research

• 11Clinical trials
• 97NIH research projects
• 15Countries

Newest Arterial Hypertension clinical trials

All recruiting trials (11)

• Observational register of adults with diabetes and endocrine/metabolic disorders

  This study will collect medical information from adults with diabetes or related metabolic and endocrine conditions to see how markers relate to disease severity and progression.

  Recruiting IRCCS San Raffaele · Milan, Italy · NCT07206875

• Reliability of Two-Stage Multiple-Repetition-Maximum Tests to Estimate 1-RM in People with Heart Disease and Risk Factors

  This study checks how well different formulas estimate the 1-RM from two submaximal tests in adults with heart disease or risk factors.

  Recruiting Technical University of Munich · München · NCT06796582

• Registry for studying hypertension types and treatment in Morocco

  This study is collecting health information from adults with high blood pressure in Morocco to see how different types of hypertension are treated and to improve care for patients.

  Recruiting at 5 sites Moroccan Society of Cardiology · Meknes, Morocco and 4 other locations · NCT06769269

• Telemedical support for managing high blood pressure

  This study is testing a new remote blood pressure monitoring system to see if it helps doctors better manage high blood pressure in adults who have trouble controlling it.

  Recruiting Poznan University of Medical Sciences · Poznan · NCT06722625

• Using AI to analyze heart changes in patients with high blood pressure

  This study is testing if artificial intelligence can help doctors understand heart changes in patients with high blood pressure by analyzing their heart scans and health information.

  Recruiting Hospices Civils de Lyon · Pierre-Bénite · NCT06680986

• Nitrate supplementation effects on blood pressure in resistant hypertension patients

  This study tests if taking beetroot extract can help lower blood pressure in people with resistant hypertension who haven't changed their blood pressure medications recently.

  Recruiting Early Phase 1 National Institute of Cardiology, Laranjeiras, Brazil · Rio de Janeiro · NCT06169241

• Using Fetuin A to Predict Kidney Function Decline in Patients with High Blood Pressure

  This study is testing if a substance in urine called Fetuin A can help predict kidney problems in people with high blood pressure.

  Recruiting University Hospital Ostrava · Ostrava, Czech Republic · NCT05963126

• Understanding chronic kidney disease in Sub-Saharan Africa

  This study is trying to understand how common chronic kidney disease is in Sub-Saharan Africa and what factors might be causing it by looking at the health and lifestyle of adults in the Bagamoyo district.

  Recruiting Swiss Tropical & Public Health Institute · Bagamoyo, Pwani Region · NCT05881447

• Screening patients at risk for liver disease in Europe

  This study is trying to find out if screening high-risk patients in Europe for liver disease using simple tests can help doctors identify and better understand conditions like metabolic dysfunction-associated steatotic liver disease.

  Recruiting at 6 sites Julius Clinical · Brussels, Vlaams-brabant and 12 other locations · NCT05651724

• Renal denervation for women with hypertension planning pregnancy

  This study tests if a procedure called renal denervation can help women with high blood pressure who are planning to get pregnant manage their condition better.

  Recruiting at 4 sites University Hospital, Bordeaux · Bordeaux and 5 other locations · NCT05563337

• High blood pressure registry

  This project gathers medical data from adults with high blood pressure to see how primary care clinics follow current treatment recommendations.

  Recruiting at 17 sites National Medical Research Center for Cardiology, Ministry of Health of Russian Federation · Moscow, Moscow Oblast and 16 other locations · NCT04160533

NIH-funded research (newest 40 of 97)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding how blood flow and pressure affect lungs in PAH

  This grant studies how abnormal blood flow and pressure contribute to pulmonary arterial hypertension and how patient factors shape these effects, with the aim of guiding better therapies.

  NIH research University of Washington · Seattle, United States · NIH-11531183

• Asporin as a double-targeted therapy and biomarker for a serious artery disease

  This project tests a protein called asporin as both a treatment and a biomarker for pulmonary arterial hypertension (PAH) to help people with this life-threatening condition.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11450594

• Platelets and fibroblasts linked to energy use in a hard-to-treat blood vessel disease

  A research team at the University of Pittsburgh is studying how platelet energy metabolism and fibroblast glutamine use interact in systemic sclerosis-related pulmonary arterial hypertension to improve diagnosis and treatment.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11419895

• A biatrial dual‑lumen catheter to help the heart and lungs in pulmonary arterial hypertension

  A new double‑lumen catheter is being developed to unload the right side of the heart and protect the lungs for people with pulmonary arterial hypertension.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11418121

• Endothelial inflammation and Src kinase in early pulmonary arterial hypertension

  Researchers are studying how inflammation in the lining of blood vessels and a protein called Src kinase contribute to early lung artery remodeling in people with mild PAH.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11411210

• Cardiopulmonary chip model to study right heart disease from high blood pressure in the lungs

  A tiny heart-lung chip is being developed to understand why the right side of the heart enlarges in people with pulmonary arterial hypertension and to test targeted treatments.

  NIH research Medluidics LLC · Elk Grove, United States · NIH-11410451

• Empagliflozin to Improve Right Ventricular Function in Pulmonary Arterial Hypertension

  A 3-center, placebo-controlled study tests whether daily 10 mg empagliflozin for 24 weeks can help heart function and other outcomes in people with PAH.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11399092

• Empagliflozin to Help the Right Heart in PAH

  A patient-focused trial will test whether empagliflozin can improve the right heart’s function in people with pulmonary arterial hypertension.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11398874

• Move PAH: a mobile health program to boost daily activity and quality of life for people with pulmonary arterial hypertension

  A smartphone-based program uses text messages and activity data to help people with PAH be more active and feel better.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11396552

• Kynurenine pathway in pulmonary arterial hypertension and its impact on lung blood vessels

  A Johns Hopkins-led study will explore how a body chemistry pathway called kynurenine might drive changes in the lungs of people with pulmonary arterial hypertension (PAH).

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11396550

• RASA3 gene role in pulmonary arterial hypertension

  A scientist will study how the RASA3 gene affects cells in pulmonary arteries to understand a severe lung condition called PAH.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11396286

• Integrative multiomics to find genes and networks in PAH

  This NIH grant supports a clinician-scientist at UCLA to map genes and networks involved in pulmonary arterial hypertension using cutting-edge multiomics.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11393638

• Endothelial and smooth muscle cell programs in pulmonary arterial hypertension

  A study in mice will map how genes in lung blood vessel cells influence pulmonary arterial hypertension and identify factors that might protect against or worsen the disease.

  NIH research Stanford University · Stanford, United States · NIH-11391267

• Understanding right heart fat in PAH and how it affects function

  This NIH grant studies why the right side of the heart accumulates fat in people with pulmonary arterial hypertension and how that affects exercise and heart failure.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11385327

• Biatrial catheter to support the heart and lungs in pulmonary arterial hypertension

  A small, patient-friendly device is being developed to temporarily support the heart and lungs in people with pulmonary arterial hypertension.

  NIH research Sentara Health · Virginia Beach, United States · NIH-11384970

• Carnitine supplementation for the heart’s right side in PAH

  This project tests whether taking carnitine can help improve heart function and quality of life for people with pulmonary arterial hypertension.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11370500

• One versus two medicines for children with pulmonary arterial hypertension

  This compares starting one medicine versus starting two medicines for children with pulmonary arterial hypertension to find which approach helps symptoms, exercise ability, and heart health.

  NIH research Duke University · Durham, United States · NIH-11364147

• Single versus combination oral treatment for children with pulmonary arterial hypertension

  This project compares starting one oral PAH medicine versus starting two (sildenafil plus bosentan) right away in children with pulmonary arterial hypertension to see which approach better helps breathing, heart function, and daily life.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11364094

• Identifying somatic mutations linked to pulmonary arterial hypertension

  A patient-facing study exploring whether somatic mutations in lung blood vessel pathways contribute to PAH, potentially revealing new clues for diagnosis or treatment.

  NIH research University of Washington · Seattle, United States · NIH-11363395

• Gut Restore-PAH: Microbiota Transplant to Help Pulmonary Angiopathy

  A small pilot study will test whether transplanting healthy gut bacteria, with antibiotics beforehand and fiber support, can help people with pulmonary arterial hypertension.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11354274

• Systemic consequences of PAH on lean muscle mass in PAH patients

  This project looks at why people with pulmonary arterial hypertension lose muscle mass and how that affects their health and daily life.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11345642

• Revumenib as an epigenetic treatment for pulmonary arterial hypertension

  This project looks at whether the drug revumenib can reverse harmful cell changes that narrow lung arteries in people with pulmonary arterial hypertension.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11338930

• Role of CES1 in lung blood vessel health and PAH biology

  This NIH grant explores how a liver enzyme, CES1, helps lung blood vessels stay healthy and may drive pulmonary arterial hypertension in people.

  NIH research Stanford University · Stanford, United States · NIH-11332306

• Vps34 in Pulmonary Hypertension: A Pathway to Safer, Stronger Lungs

  Aims to understand how a cellular pathway (Vps34) drives abnormal blood vessel remodeling in pulmonary hypertension and test strategies to slow or stop this process.

  NIH research State University of Ny,binghamton · Binghamton, United States · NIH-11331310

• Targeting FAK-NEDD9 to slow PAH-related vessel remodeling

  A new approach aims to block a key protein interaction in the lungs to slow blood vessel remodeling in pulmonary arterial hypertension.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11324945

• NOTCH3 blood marker for pulmonary arterial hypertension

  This project looks for a NOTCH3 protein fragment in blood to help detect and monitor pulmonary arterial hypertension in people with PAH.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11310864

• Pulmonary hypertension risk in systemic sclerosis linked to a DNASE1L3 genetic variant

  A small study is looking at how a specific genetic change in DNASE1L3 might raise the risk of lung blood-vessel problems in people with systemic sclerosis.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11289756

• ARID1A and the gene 'switches' that shape pulmonary arterial hypertension

  This project looks at whether changes in the ARID1A gene and related epigenetic switches drive the blood-vessel scarring that causes pulmonary arterial hypertension.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11289363

• Investigating a protein's role in lung blood vessel disease

  This study is looking at how a protein called Vps34 affects the growth of certain cells in the lungs of people with pulmonary arterial hypertension (PAH), with the hope of finding new ways to treat this serious condition.

  NIH research State University of Ny,binghamton · Binghamton, United States · NIH-11269309

• HIPK2 and blood vessel remodeling in pulmonary arterial hypertension

  Researchers are testing whether blocking the HIPK2 protein can reduce the abnormal growth of lung artery muscle cells and help people with pulmonary arterial hypertension.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11261617

• Lung-targeted serotonin blocker for pulmonary arterial hypertension

  Developing lung-focused medicines that block a serotonin receptor to help people with pulmonary arterial hypertension.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11261527

• How the right side of the heart uses energy in pulmonary arterial hypertension

  This project looks at how the right ventricle's blood flow and energy change over time in people with pulmonary arterial hypertension using a 3D echocardiogram technique.

  NIH research University of California-Irvine · Irvine, United States · NIH-11249689

• Pericytes' role in small blood-vessel changes in pulmonary arterial hypertension

  This project looks at whether malfunctioning pericytes — the cells that support tiny lung blood vessels — drive harmful vessel remodeling in people with pulmonary arterial hypertension.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11247521

• Lactate and LDHA in pulmonary arterial hypertension

  This work looks at how excess lactate made by artery cells may drive thickening of lung blood vessels in people with pulmonary arterial hypertension.

  NIH research University of California at Davis · Davis, United States · NIH-11235916

• Investigating how ion channels and membrane receptors affect pulmonary arterial hypertension

  This study is looking into how certain proteins and channels in the blood vessels of the lungs might cause problems for people with pulmonary arterial hypertension (PAH), with the goal of finding new ways to help improve their health.

  NIH research University of Florida · Gainesville, United States · NIH-11228445

• Empagliflozin for right heart function in pulmonary arterial hypertension

  This project will see if empagliflozin, a diabetes drug, can help the right side of the heart work better in people with pulmonary arterial hypertension.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11199033

• Understanding physical activity patterns in patients with pulmonary arterial hypertension.

  This study looks at how staying active impacts people with pulmonary arterial hypertension (PAH) by using special devices to track their daily movements, with the goal of creating personalized exercise plans that can help improve their health and well-being.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11194972

• Oral medicine to slow damage from pulmonary arterial hypertension

  A new oral drug called VN-1032 aims to slow blood-vessel damage in people with pulmonary arterial hypertension.

  NIH research Vasculonics, LLC · Indianapolis, United States · NIH-11193989

• Platelet and lung vessel cell metabolism in scleroderma-related pulmonary hypertension

  This project looks at whether energy changes in platelets signal lung vessel cells to change glutamine use and worsen pulmonary hypertension in people with systemic sclerosis.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11193267

• Understanding Muscle Loss in Pulmonary Arterial Hypertension

  This project aims to understand why people with pulmonary arterial hypertension (PAH) often lose muscle mass and how this affects their health.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11192240

Related topics

Quick answers

How many Arterial Hypertension clinical trials are recruiting right now?

11, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 15 countries. The most sites are in France (3 trials), Germany (2 trials), Czechia (2 trials), Italy (2 trials), Tanzania (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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