Creating a mathematical model to understand obesity-related diabetes and wound healing
Official title: Mathematical Models for Obesity-Induced Type 2 Diabetes Mellitus and Chronic Wound Healing
Funded at Rochester Institute of Technology · NIH-10937272 · Data updated 2026-11-12
This study is looking at how being overweight affects healing for people with type 2 diabetes, and it aims to create a helpful tool to better understand and improve care for those dealing with diabetes and slow-healing wounds.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rochester Institute of Technology NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 3, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $176,840 |
| NIH project number | 1R16GM154782-01 |
| Project ID | NIH-10937272 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 65 and older who are experiencing obesity and related complications such as type 2 diabetes and chronic wounds.
✕Less likely to help
Patients who are not affected by obesity or do not have diabetes or chronic wounds may not benefit from this research.
What this research studies
This research aims to develop a predictive mathematical model that explores the relationship between obesity, type 2 diabetes, and chronic wound healing. By incorporating key physiological factors and a detailed analysis of glucose and glycogen exchange in the liver, the project seeks to better understand how obesity contributes to these conditions. The model will focus on dynamic variables rather than constant parameters, allowing for a more accurate representation of the factors that impair healing in diabetes patients. This innovative approach could lead to improved strategies for managing diabetes and related complications.
Why it matters
Potential benefit: If successful, this research could lead to better management and treatment options for patients suffering from obesity-related diabetes and chronic wounds.
How similar studies have gone: While the approach of using mathematical modeling in this context is innovative, similar studies have shown promise in understanding complex interactions in diabetes management.
Where this research is happening
-
Rochester Institute of Technology
Rochester, United States Active
Researchers
- Principal investigator: Siewe, Nourridine — Rochester Institute of Technology
- Study coordinator: Siewe, Nourridine
Related research
Other NIH-funded projects on the same topics.
-
Predicting obesity-related diabetes and wound healing with math models
A math-based model is being built to better understand how obesity drives type 2 diabetes and slow wound healing in adults.
-
Exploring new muscle chemistry in adults with Type 2 diabetes
A study will test a new imaging method to measure muscle metabolites in adults with Type 2 diabetes to better understand how the disease affects their muscles.
-
Save with Care: Help with costs to manage type 2 diabetes
A digital program helps adults with type 2 diabetes on high-deductible plans save money and get better access to care.
-
Improving heart- and kidney-protective treatment for people with type 2 diabetes and chronic kidney disease
This project will help people with type 2 diabetes and chronic kidney disease get proven medicines that protect the heart and kidneys but are often missed.
-
Personalized nutrition guided by continuous glucose monitors for type 2 diabetes
See whether using continuous glucose monitors to tailor meals helps adults with type 2 diabetes keep blood sugar under better control.
-
Reducing food insecurity for African American adults with diabetes
This study is looking at how not having enough food affects African American adults with Type 2 diabetes and is testing whether sending them food boxes or giving them food vouchers helps them manage their blood sugar better, or if using both together works best.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.