Understanding how diabetes affects insulin secretion in the body
Official title: Mechanism of Defective Incretin Action in Beta Cells during Type 2 Diabetes Mellitus
Funded at University of California-Irvine · NIH-11087709 · Data updated 2026-11-12
This study is looking into why certain hormones that help your body produce insulin don't work as well in people with Type 2 Diabetes, and it hopes to find new ways to improve treatment for those living with the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | July 1, 2021 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $460,862 |
| NIH project number | 5R01DK130256-05 |
| Project ID | NIH-11087709 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Type 2 Diabetes Mellitus who experience challenges with insulin secretion.
✕Less likely to help
Patients without Type 2 Diabetes or those with other forms of diabetes may not benefit from this research.
What this research studies
This research investigates the mechanisms by which incretin hormones, which are crucial for insulin secretion, are impaired in patients with Type 2 Diabetes Mellitus (T2DM). It focuses on how these hormones, specifically glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1), interact with beta cells in the pancreas and why their effectiveness is reduced in T2DM. By examining the molecular pathways involved, the research aims to uncover the reasons behind the diminished response to these hormones in diabetic patients, which could lead to new therapeutic strategies. The study employs biochemical and molecular biology techniques to analyze the signaling pathways affected by diabetes.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for Type 2 Diabetes by enhancing insulin secretion mechanisms.
How similar studies have gone: Previous research has shown that enhancing incretin hormone levels can improve insulin secretion in diabetic patients, indicating a promising area of study.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Hussain, Mehboob a — University of California-Irvine
- Study coordinator: Hussain, Mehboob a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.