Using brain stimulation to reduce tremors in Parkinson's disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the use of cerebellar transcranial alternating current stimulation (tACS) to modulate hand tremors in patients with Parkinson's disease. It employs a closed-loop system that synchronizes stimulation with the patient's intrinsic tremor signal, aiming to reduce tremor severity. The study will compare the effects of active tACS against sham and unlocked tACS treatments to evaluate efficacy. By targeting the cortico-thalamo-cortical network, this approach seeks to address the underlying neurophysiological mechanisms of tremor.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Clinical diagnosis of Parkinson's disease based on UK Brain Bank criteria
* Patient exhibiting moderate to severe hand tremor
* Provision written informed consent by the patient

Exclusion Criteria:

* History of other neurological disorders such as vascular malformations, ischemic or haemorrhagic stroke, cerebral neoplasia, epilepsy, or major psychiatric illness
* Existence of heart pacemaker or metal implants in the body
* Pregnancy

Where it's running

• Universitätsklinikum Hamburg-Eppendorf
  Hamburg, Free and Hanseatic City of Hamburg, Germany Recruiting

Study contacts

• Study coordinator: Simone Zittel, Dr. med.
• Email: s.zittel-dirks@uke.de
• Phone: +49 40 7410 53770

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.