Understanding sensory sensitivity in Tourette Syndrome
Official title: Neurophysiologic Correlates of Sensory Over-Responsivity in Tourette Syndrome
Funded at Vanderbilt University Medical Center · NIH-11039948 · Data updated 2026-11-12
This study is looking into how people with Tourette Syndrome, both kids and adults, react strongly to sensory experiences, like sounds or textures, to better understand why this happens and how it affects their daily lives.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | March 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $176,646 |
| NIH project number | 5K23NS131592-03 |
| Project ID | NIH-11039948 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include individuals diagnosed with Tourette Syndrome, particularly those experiencing sensory over-responsivity.
✕Less likely to help
Patients without a diagnosis of Tourette Syndrome or those not experiencing sensory over-responsivity may not benefit from this research.
What this research studies
This research investigates the neurophysiological mechanisms behind sensory over-responsivity (SOR) in individuals with Tourette Syndrome (TS). It aims to explore how heightened awareness and reactions to sensory stimuli affect patients, particularly focusing on both children and adults. By examining the clinical significance and biological underpinnings of SOR, the study seeks to improve understanding of this common yet under-researched aspect of TS. Participants may undergo assessments and evaluations to help identify the neurobiological factors contributing to their sensory experiences.
Why it matters
Potential benefit: If successful, this research could lead to better management strategies for sensory symptoms in patients with Tourette Syndrome.
How similar studies have gone: Previous research has indicated that understanding sensory processing in movement disorders can lead to significant advancements in treatment, suggesting potential success for this approach.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Isaacs, David a — Vanderbilt University Medical Center
- Study coordinator: Isaacs, David a
Related research
Other NIH-funded projects on the same topics.
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Precision brain mapping of tics in children with Tourette syndrome
A new study uses advanced MRI to map brain activity in individual kids with Tourette syndrome to understand why tics differ from child to child.
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Digital tic-detection partner to support Tourette syndrome therapy
A computer vision system will help detect tics in children and youths with Tourette syndrome to support behavioral therapy at home and in real life.
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Quantifying Tourette tics with video and computer tools
This project aims to develop and test video-based, automated ways to measure tic severity in people with Tourette Syndrome.
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Brain-feedback training to help teens with Tourette control tics
This project teaches teenagers with Tourette syndrome to use real-time MRI brain-feedback to change activity in a motor brain area with the goal of reducing tics.
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International collaboration mapping genes and brain scans in Tourette syndrome
This project brings together MRI brain scans and genetic data from people with Tourette syndrome and related conditions to spot biological patterns linked to tics and co-occurring symptoms.
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How Tourette syndrome develops in the brain
Researchers are using donated brain tissue and patient-derived stem cells to learn why people with Tourette syndrome have fewer specific brain cells in the basal ganglia.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.