Understanding the neurodevelopment of Tourette syndrome
Neurodevelopment of Tourette syndrome
This study is looking at how genes and brain development might affect Tourette syndrome by examining brain tissue and special lab-grown brain cells, with the goal of finding out what causes TS and how we can better treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11048424 on NIH RePORTER |
What this research studies
This research investigates the genetic and developmental factors contributing to Tourette syndrome (TS) by examining brain tissue and using advanced techniques like organoids derived from patient stem cells. The study focuses on the cortico-striatal-thalamo-cortical circuits, which are believed to play a crucial role in TS. By analyzing the number of specific types of neurons in the brain and their development, researchers aim to uncover the underlying causes of TS and identify potential biomarkers for the condition. This research could lead to a better understanding of TS and inform future treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Tourette syndrome, particularly those with a familial history of the condition.
Not a fit: Patients without a diagnosis of Tourette syndrome or those with other unrelated neuropsychiatric disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and targeted therapies for individuals with Tourette syndrome.
How similar studies have performed: Previous research has shown promise in understanding neurodevelopmental disorders through similar methodologies, indicating potential for success in this area.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Vaccarino, Flora M — Yale University
- Study coordinator: Vaccarino, Flora M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.