Personalized neurostimulation for Tourette's Syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of personalized responsive neurostimulation (RNS) therapy in patients with treatment-resistant Tourette's Syndrome (TR-TS). It utilizes stereoelectroencephalography (SEEG) to identify individualized stimulation targets in the brain, aiming to alleviate severe tics that have not responded to conventional treatments. The study focuses on patients aged 18-65 who have experienced significant symptoms for at least 12 months and have failed multiple medication classes. By mapping neuronal activity in specific brain regions, the study seeks to provide a tailored approach to managing TR-TS.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. aged 18-65;
2. able to provide written informed consent;
3. have a diagnosis of Tourette's syndrome according to the Statistical Manual of Mental Disorders-Fourth Edition-Text Revised (DSM-IV-TR) criteria and confirmed by the Mini-International Neuropsychiatric Interview Chinese version 5.0;
4. with a YGTSS of at least 35 for at least 12 months before surgery, while YGTSS- Total Motor≥15;
5. must have failed conventional medical treatment at adequate therapeutic doses of three classes of medication lasting for at least three months;
6. must not be suitable for behavioural intervention or that this intervention is inappropriate or unsuccessful;
7. have been on stable comorbid conditions without suicidal ideation for at least six months.

Exclusion Criteria:

1. presence of other psychotic disorders;
2. have a treatment history that includes electroconvulsive therapy (ECT), modified electroconvulsive therapy (MECT), transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), DBS, and transcranial magnetic stimulation (TMS);
3. presents a suicide risk (defined as a HAMD-17 score of ≥3 on suicide-related items);
4. experience difficulty in effectively communicating with investigators;
5. with a history of traumatic brain injury (TBI);
6. with intracranial or cardiovascular stents;
7. substance abuse within the past six months;
8. unstable neurological or coagulation disorders;
9. women who are pregnant, lactating, or of childbearing potential who refuse the use of reliable contraception during the study;
10. have been involved in other clinical studies within three months before enrollment in this study;
11. any conditions considered by the study group.

Where it's running

• Xuanwu Hospital, Capital Medical University
  Beijing, China Recruiting

Study contacts

• Principal investigator: Hongxing Wang, MD & PhD — Xuanwu Hospital, Beijing
• Study coordinator: Hongxing Wang, MD & PhD
• Email: wanghongxing@xwh.ccmu.edu.cn
• Phone: +861083198650

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Study of brain activity in patients with Tourette Syndrome

  This study is testing how brain activity changes in adults with severe Tourette Syndrome who are getting deep brain stimulation to better understand their tics.

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• Personalized deep brain stimulation for Tourette syndrome

  This study is testing if personalized deep brain stimulation can help people with Tourette syndrome reduce their tics and improve related issues like anxiety and attention problems.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT06889480

• Cognitive-psychophysiological therapy, with or without biofeedback, for tics in young people with Tourette's

  This project tests whether adding biofeedback to cognitive-psychophysiological therapy helps reduce tics in 14–21-year-olds with Tourette's.

  Recruiting Université du Québec a Montréal · Montreal, Quebec · NCT06873841

• Understanding changes in Tourette Syndrome

  This study is trying to learn how Tourette Syndrome and tic disorders change over time in kids by using new technology to track their symptoms.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT06679790

• Treatment for chronic tics in youth using behavioral therapy and brain stimulation

  This study is testing whether combining a special therapy for tics with a type of brain stimulation can help young people with Tourette Syndrome better control their tics.

  Recruiting Phase 2 University of Minnesota · Minneapolis, Minnesota · NCT06678737

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.