Investigating how neuroactive steroids affect Tourette syndrome
Exploring the role of neuroactive steroids in Tourette syndrome
['FUNDING_R21'] · UNIVERSITY OF UTAH · NIH-10656348
This study is looking at how certain brain chemicals might affect the symptoms of Tourette syndrome, especially in boys, and how stress can make tics worse, with the hope of finding new ways to help manage the condition.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF UTAH (nih funded) |
| Locations | 1 site (SALT LAKE CITY, UNITED STATES) |
| Trial ID | NIH-10656348 on ClinicalTrials.gov |
What this research studies
This research explores the biological mechanisms behind Tourette syndrome (TS), focusing on how neuroactive steroids may influence the disorder's symptoms. Researchers will examine the role of these steroids in relation to the male predominance of TS and how stress impacts tic expression. By studying animal models, the team aims to uncover how specific neuroactive steroids, like DHEA and allopregnanolone, affect tic behavior and the brain's ability to manage these tics. The findings could lead to a better understanding of TS and potential new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Tourette syndrome, particularly those experiencing significant tic symptoms.
Not a fit: Patients without a diagnosis of Tourette syndrome or those whose symptoms are well-managed may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for Tourette syndrome, enhancing the quality of life for affected individuals.
How similar studies have performed: While the specific focus on neuroactive steroids in TS is relatively novel, previous studies have shown promise in understanding the biological underpinnings of similar neurodevelopmental disorders.
Where this research is happening
SALT LAKE CITY, UNITED STATES
- UNIVERSITY OF UTAH — SALT LAKE CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BORTOLATO, MARCO — UNIVERSITY OF UTAH
- Study coordinator: BORTOLATO, MARCO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.