Investigating a gene linked to Tourette syndrome
Exploring the role of the protocadherin CELSR3 in Tourette syndrome
This study is looking at how a specific gene called CELSR3 might be linked to Tourette syndrome, using special mice to see how changes in this gene could help us understand the condition better and find new treatments for people with TS.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10532254 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic factors contributing to Tourette syndrome (TS), particularly the role of the CELSR3 gene. By using transgenic mouse models with mutations in this gene, researchers aim to uncover how CELSR3 deficiency may lead to the development of TS. The study builds on recent findings that suggest protocadherins, proteins involved in cell communication, are significant in TS pathogenesis. This work could provide insights into more effective treatments for individuals affected by TS.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Tourette syndrome, particularly those with a family history of the disorder.
Not a fit: Patients without a diagnosis of Tourette syndrome or those with other unrelated neurological disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that specifically address the underlying genetic causes of Tourette syndrome, improving treatment outcomes for patients.
How similar studies have performed: Previous research has shown promising results in understanding genetic contributions to Tourette syndrome, making this approach a continuation of successful investigations in the field.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Bortolato, Marco — University of Utah
- Study coordinator: Bortolato, Marco
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.