Study of brain activity in patients with Tourette Syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the electrophysiological characteristics of brain activity in individuals with Tourette Syndrome (TS) who are undergoing deep brain stimulation treatment. By utilizing multimodal electrophysiological recordings, the research aims to identify specific cortico-subcortical biomarkers associated with tics. The study focuses on patients aged 16 and older who have disabling and drug-resistant TS, providing insights into the underlying mechanisms of the disorder. The findings could enhance understanding of TS and inform future treatment strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient at least 16 years old.
* Disabling and drug-resistant Tourette's syndrome.
* Receiving deep brain stimulation treatment with implantation of the PERCEPT™ Device as part of their medical management.
* Normal brain MRI.
* Subject affiliated or beneficiary of a social security system.
* Free and informed consent of the patient and, for minors, of the minor and at least one parental authority.

Exclusion Criteria:

* Major depressive syndrome (Beck Depression Inventory (BDI-II) \> 20).
* MRI showing significant brain atrophy or significant hyperintensities.
* Pregnant or nursing mothers.
* Person unable to give personal consent.
* Person subject to a legal protection measure (curatorship, guardianship) or placed under court protection.
* Patient included in another research protocol with an interdiction of participation to another research or in an exclusion period

Where it's running

• CHU de Bordeaux
  Bordeaux, France Recruiting

Study contacts

• Principal investigator: Edouard COURTIN, Dr — University Hospital, Bordeaux
• Study coordinator: Edouard COURTIN, Dr
• Email: edouard.courtin@chu-bordeaux.fr
• Phone: 05 57 82 12 42

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Treatment for chronic tics in youth using behavioral therapy and brain stimulation

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.