Study of brain activity in patients with Tourette Syndrome
Multimodal Electrophysiological Study of Cortico-subcortical Biomarkers of Tics in Tourette Syndrome
This study is testing how brain activity changes in adults with severe Tourette Syndrome who are getting deep brain stimulation to better understand their tics.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 10 (estimated) |
| Ages | 16 Years and up |
| Sex | All |
| Sponsor | University Hospital, Bordeaux Academic / other |
| Locations | 1 site (Bordeaux) |
| Trial ID | NCT06909656 on ClinicalTrials.gov |
What this trial studies
This study investigates the electrophysiological characteristics of brain activity in individuals with Tourette Syndrome (TS) who are undergoing deep brain stimulation treatment. By utilizing multimodal electrophysiological recordings, the research aims to identify specific cortico-subcortical biomarkers associated with tics. The study focuses on patients aged 16 and older who have disabling and drug-resistant TS, providing insights into the underlying mechanisms of the disorder. The findings could enhance understanding of TS and inform future treatment strategies.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals aged 16 and older with disabling and drug-resistant Tourette Syndrome who are receiving deep brain stimulation.
Not a fit: Patients with major depressive syndrome or significant brain abnormalities may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment options for patients with Tourette Syndrome.
How similar studies have performed: Other studies have explored electrophysiological approaches in neurological disorders, suggesting potential for success in this area.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient at least 16 years old. * Disabling and drug-resistant Tourette's syndrome. * Receiving deep brain stimulation treatment with implantation of the PERCEPT™ Device as part of their medical management. * Normal brain MRI. * Subject affiliated or beneficiary of a social security system. * Free and informed consent of the patient and, for minors, of the minor and at least one parental authority. Exclusion Criteria: * Major depressive syndrome (Beck Depression Inventory (BDI-II) \> 20). * MRI showing significant brain atrophy or significant hyperintensities. * Pregnant or nursing mothers. * Person unable to give personal consent. * Person subject to a legal protection measure (curatorship, guardianship) or placed under court protection. * Patient included in another research protocol with an interdiction of participation to another research or in an exclusion period
Where this trial is running
Bordeaux
- CHU de Bordeaux — Bordeaux, France (Recruiting)
Study contacts
- Principal investigator: Edouard COURTIN, Dr — University Hospital, Bordeaux
- Study coordinator: Edouard COURTIN, Dr
- Email: edouard.courtin@chu-bordeaux.fr
- Phone: 05 57 82 12 42
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.