Using TMS to enhance behavioral therapy for Tourette Syndrome
Strengthening Tourette Treatment OPtions Using TMS to Improve CBIT, a Double-blind, Randomized, Controlled Study
NA · West Virginia University · NCT05705999
This study is testing if adding a brain stimulation treatment to behavioral therapy can help adults with Tourette Syndrome reduce their tics more effectively.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years to 100 Years |
| Sex | All |
| Sponsor | West Virginia University (other) |
| Locations | 1 site (Morgantown, West Virginia) |
| Trial ID | NCT05705999 on ClinicalTrials.gov |
What this trial studies
This pilot study investigates the effects of repetitive transcranial magnetic stimulation (rTMS) combined with comprehensive behavioral intervention for tics (CBIT) in adults with Tourette Syndrome. Participants with moderate tic severity will be randomly assigned to receive either active or sham rTMS targeting the supplementary motor area, followed by eight sessions of CBIT. The study aims to measure changes in tic frequency and severity, as well as neurophysiological changes, comparing outcomes between the two groups. The hypothesis is that rTMS will enhance the effectiveness of CBIT by positively influencing the SMA network.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older diagnosed with Tourette Syndrome and exhibiting moderate tic severity.
Not a fit: Patients with contraindications to rTMS, such as those with metallic implants or a history of seizures, may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve tic management for patients with Tourette Syndrome.
How similar studies have performed: While this approach is innovative, similar studies using rTMS for neurological conditions have shown promising results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 years or older * Diagnosis of Tourette Syndrome * Moderate Tic Severity at baseline Exclusion Criteria: * Presence of metallic objects or neurostimulators in the brain * Pregnancy * History of active seizures or epilepsy * Contraindications to receiving fMRI * Inability to participate in CBIT due to other underlying cognitive or medical condition
Where this trial is running
Morgantown, West Virginia
- WVU RNI — Morgantown, West Virginia, United States (RECRUITING)
Study contacts
- Principal investigator: Jessica Frey, MD — WVU RNI
- Study coordinator: Jessica Frey, MD
- Email: Jessica.frey@hsc.wvu.edu
- Phone: 304-598-6127
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Tourette Syndrome, Comprehensive Behavioral Intervention for Tics, Transcranial Magnetic Stimulation