Condition

Tooth Loss clinical trials and research

• 22Clinical trials
• 4NIH research projects
• 17Countries

Newest Tooth Loss clinical trials

All recruiting trials (22)

• Effect of four post-extraction socket approaches on preserving the ridge after tooth removal

  This study tests four ways to care for an extraction socket to see which best preserves the jawbone and gum after tooth removal for future implants.

  Recruiting Universidad del Desarrollo · Santiago, Santiago Metropolitan · NCT07812883

• Immediate molar implants with customized healing abutments in different socket classes

  This study tests placing an implant right after extracting a back tooth and using a custom healing cap to shape the gum from day one, in people needing posterior implants.

  Recruiting Plovdiv Medical University · Plovdiv · NCT07801573

• Use of enamel matrix derivative with immediate implants in the lower back teeth

  This trial tests whether applying enamel matrix derivative at the time of immediate mandibular molar implants helps osseointegration and healing.

  Recruiting Mansoura University · Al Mansurah, Dakahlia Governorate · NCT07727655

• Soft tissue augmentation around dental implants using connective tissue graft or less invasive approaches

  This trial tests three ways to increase the soft tissue around a dental implant in adults with thin gums to see which method works best.

  Recruiting Misr International University · Cairo · NCT07714265

• Biodontoss and DWC dental implants and superstructures in adults needing tooth replacement

  This PMCF study tests whether BIODENTOSS and DWC dental implants and their superstructures are safe and effective for adults with tooth loss over 24 months.

  Recruiting Değirmenci Otomotiv ve Metal Endüstri A.Ş. · Konya · NCT07633665

• Temporary dental crowns and bridges using ON DENT materials

  This PMCF study tests whether ON DENT temporary crowns and bridges perform safely and survive as patients wear them while awaiting final prostheses.

  Recruiting On Dent Tibbi Malzeme Dis Protez Ith. ve Ihr. San. Ltd. Sti. · Izmir · NCT07632443

• How full-arch dental implants affect oral health quality of life

  This study will test whether full-arch implant-supported prostheses improve oral health-related quality of life and satisfaction for people who are missing most or all teeth.

  Recruiting Implantology Institute · Lisbon, Lisbon District · NCT07568249

• Straumann Falcon dynamic navigation for guided dental implant placement

  This study will test if the Straumann Falcon navigation system helps dentists place dental implants more safely and more accurately in adults missing some teeth.

  Recruiting at 2 sites Institut Straumann AG · Ghent and 3 other locations · NCT07518615

• Autotransplantation of a patient's own tooth using simulated open apex and platelet-rich fibrin

  We will try transplanting patients' own fully developed teeth using a simulated open apex technique plus platelet-rich fibrin to encourage revascularization and help younger people or others who cannot get implants.

  Recruiting University of Bari Aldo Moro · Bari · NCT07393997

• Premolar autotransplantation to replace upper front teeth in young patients

  This project will test whether transplanting a premolar into the upper front jaw helps children aged 7–15 regain tooth function and appearance.

  Recruiting University of Barcelona · Barcelona, Barcelons · NCT07314580

• Nobel N1 dental implant with early 6-week crown placement

  This test will see if adults missing a single back tooth can get a final crown on a Nobel N1 dental implant 6 weeks after implant surgery.

  Recruiting Phase 4 Louisiana State University Health Sciences Center in New Orleans · New Orleans, Louisiana · NCT07280260

• Immediate short implants to replace a single extracted tooth

  This study will test whether placing short dental implants right after removing a single tooth in patients with limited bone provides solid support and healthy gum and bone healing.

  Recruiting University of Bari Aldo Moro · Bari · NCT07177521

• Evaluation of biomimetic abutments for dental implants

  This study tests if using special healing and prosthetic parts for dental implants can improve healing and overall results for patients getting dental restorations.

  Recruiting Stomatological Hospital Affiliated with Fujian Medical University · Fuzhou, Fujian · NCT06870955

• Examining gum changes after removing an implant crown

  This study is testing how the gums change after taking off an implant crown to see how long it takes for those changes to happen, which is important for making new crowns look good.

  Recruiting Loma Linda University · Loma Linda, California · NCT06783595

• Evaluating healing time effects on tooth extraction socket preservation

  This study is testing if waiting 3 months or 6 months after a tooth extraction helps the area heal better before getting an implant, specifically for people with gum disease.

  Recruiting Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University · Shanghai · NCT06654141

• Evaluation of customized dental implants over three years

  This study is testing how well personalized dental implants work for patients over three years compared to regular implants, looking at things like comfort and how well they last.

  Recruiting University of Sao Paulo · São Paulo · NCT06576284

• Evaluation of the TSX Dental Implant System for Tooth Loss

  This study is testing the TSX Dental Implant System to see how well it works for people who need dental implants in their upper or lower jaw.

  Recruiting ZimVie · Columbus, Ohio and 1 other locations · NCT06571812

• Comparing one-piece and two-piece ceramic dental implants for tooth loss

  This study is testing whether one-piece or two-piece ceramic dental implants work better for adults with missing teeth and if there are any problems with each type.

  Recruiting at 2 sites CeraRoot SL · Boulder, Colorado and 1 other locations · NCT06287346

• Using PEEK for Removable Partial Dentures

  This study tests if removable partial dentures made from a special material called PEEK can improve the quality of life for people with missing teeth.

  Recruiting University Hospital Heidelberg · Heidelberg · NCT06191107

• Comparing one versus two visits for root canal treatments in infected teeth

  This study is testing whether getting a root canal treatment in one visit is just as effective as getting it in two visits for people with infected teeth.

  Recruiting at 4 sites Malmö University · Vaxjo, Kronoberg County and 6 other locations · NCT04605445

• How losing teeth and wearing complete dentures affect taste, mouth sensations, and food preferences

  We will test whether people who have lost all their teeth and wear complete dentures notice changes in taste, oral sensations, and food preferences compared with similar people who still have most of their natural teeth.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT04281056

• Using 3D-printed tooth replicas for tooth transplantation

  This study tests if using 3D-printed tooth replicas can help children and young adults successfully replace missing teeth better than traditional methods.

  Recruiting Turku University Hospital · Turku, Turku · NCT04120688

NIH-funded research (4)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• How HIV and HIV meds affect jaw bone and teeth

  This project looks at how HIV, its treatment, and immune changes may cause jawbone and tooth loss in people living with HIV.

  NIH research Emory University · Atlanta, United States · NIH-11596027

• Periodontitis and HIV treatment–related bone loss in the jaw and teeth

  This project studies how HIV and its treatment affect jawbone and tooth loss in people living with HIV, aiming to understand and reduce bone damage around teeth.

  NIH research Emory University · Atlanta, United States · NIH-11596026

• Periodontitis and HIV therapy–related bone loss in people living with HIV

  A study exploring how HIV treatment–related immune changes can drive bone loss around the teeth in people with HIV, and how periodontitis may worsen this effect.

  NIH research Emory University · Atlanta, United States · NIH-11323448

• How HIV and its treatment affect bone and tooth health

  This study is looking at how HIV and the medications used to treat it can affect bone health in the jaw, which is important for keeping your teeth healthy, and it's aimed at helping people living with HIV understand and improve their oral health.

  NIH research Emory University · Atlanta, United States · NIH-11144466

Related topics

Quick answers

How many Tooth Loss clinical trials are recruiting right now?

22, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 17 countries. The most sites are in United States (4 trials), Italy (3 trials), China (2 trials), Turkey (Türkiye) (2 trials), Egypt (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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