Premolar autotransplantation to replace upper front teeth in young patients
Official title: Clinical, Radiographic, Functional and Psychosocial Evaluation of Premolar Autotransplantation to the Anterior Maxillary Region in Young Patients: An Ambispective Observational Study
Run by University of Barcelona · NCT07314580 · Data updated 2026-11-12
This project will test whether transplanting a premolar into the upper front jaw helps children aged 7–15 regain tooth function and appearance.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 7 Years to 15 Years |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | University of Barcelona Academic / other |
| Locations | 1 site (Barcelona, Barcelons) |
| Status | Recruiting |
| Started | December 1, 2019 |
| Main results expected | December 31, 2029 |
| Study ends | December 31, 2029 |
| Registry record updated | January 2, 2026 |
| Trial ID | NCT07314580 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Children aged 7–15 with a missing or failing upper front tooth and an available first or second premolar donor with roughly half to complete root development are ideal candidates.
✕Probably not a fit
Patients older than 15, those lacking a suitable donor premolar, or those with severe systemic disease or inability to attend follow-up visits are unlikely to benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This ambispective observational study combines a retrospective cohort (patients treated 2019–2025) with a prospective cohort enrolled through 2028 to follow premolar autotransplantation outcomes in growing patients. Procedures follow a standardized protocol with CBCT and STL planning, 3D-printed donor replicas, guided socket preparation when needed, atraumatic extraction, extraoral time under five minutes, and semirigid splinting. Clinical, radiographic and patient-reported outcomes — including tooth survival, pulpal and periodontal healing, root development, orthodontic interactions, restorative needs, complications, and satisfaction — are recorded at set visits up to five years. Data will be analyzed to identify prognostic factors and long-term success indicators for autotransplantation in the anterior maxilla.
Why it matters
Potential benefit: If successful, this approach could restore a working, natural-looking tooth in growing patients without immediate implants or fixed prostheses.
How similar studies have gone: Previous case series and cohorts have reported good medium-term survival and periodontal outcomes with premolar autotransplantation in children, though large long-term ambispective datasets remain limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 7 to 15 years. * ASA I classification. * Loss or indication for extraction of a maxillary anterior tooth (teeth 12, 11, 21, or 22) due to trauma, resorption, or restorative reasons. * Availability of a donor first or second premolar with root development between one-half and complete root length. * Ability to complete at least 2 years of follow-up. * Parent/guardian consent and minor assent obtained for prospective cases. Exclusion Criteria: * Patients older than 15 years. * Severe systemic disease. * Inability or unwillingness to attend scheduled follow-up visits. * Lack of a suitable donor premolar.
Where it's running
-
Dental Esthetic BCN
Barcelona, Barcelons, Spain Recruiting
Study contacts
- Principal investigator: Montserrat Mercadé, PhD — Dental Esthetic BCN / Universitat de Barcelona
- Study coordinator: Montserrat Mercadé, PhD
- Email: montsemercade@ub.edu
- Phone: +34 934011235
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.