Evaluating healing time effects on tooth extraction socket preservation
Influence of Healing Time on the Outcomes of Alveolar Ridge Preservation in Periodontally Compromised Extraction Sockets: a Randomized Controlled Trial
NA · Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University · NCT06654141
This study is testing if waiting 3 months or 6 months after a tooth extraction helps the area heal better before getting an implant, specifically for people with gum disease.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 42 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University (other) |
| Locations | 1 site (Shanghai) |
| Trial ID | NCT06654141 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to assess the impact of different healing durations (3 months vs. 6 months) on the outcomes of alveolar ridge preservation in extraction sockets affected by periodontal disease. Participants will undergo tooth extraction followed by grafting with Bio-Oss Collagen® and a collagen membrane, with evaluations conducted through histological, clinical, and radiographic methods. The study seeks to determine if a shorter healing time is viable for subsequent implant placement in molar sites.
Who should consider this trial
Good fit: Ideal candidates include adults over 18 requiring molar extraction due to periodontal disease with specific radiographic findings.
Not a fit: Patients with multiple adjacent tooth extractions or acute infections may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved protocols for tooth extraction and implant placement, potentially reducing the waiting time for patients.
How similar studies have performed: Previous studies have shown varying outcomes in similar approaches, but this specific comparison of healing times is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 years of age or older * ASA (American Society of Anesthesia) status I or II * Need for molar extraction due to periodontal disease with or without chronic endodontic involvement, complying with the presentation of periodontitis stage III/IV * Radiographic evidence of a bone dehiscence on at least one socket wall, where the height of the horizontal (suprabony) component of the defect (alveolar bone crest - cement-enamel junction) is \>50% of the corresponding root length as measured on CBCT scans prior to extraction (Ben Amara et al., 2021) * Radiographic evidence of at least 3 mm of residual bone wall height * Presence of at least one adjacent tooth to the extraction site * Treatment plan must include tooth replacement with an implant-supported fixed dental prosthesis Exclusion Criteria: * Extraction of multiple adjacent teeth * Acute infection associated with the tooth to be extracted or with adjacent teeth * Current smokers (\>10 cigarettes per day) * Uncontrolled diabetes mellitus (HbA1c \>7.0) * Any active oral or systemic acute infections * Currently receiving chemo- or radiotherapy or a history of radiotherapy in the head and neck area * Diseases or medications that may compromise normal wound healing
Where this trial is running
Shanghai
- Shanghai Ninth People's Hospital — Shanghai, China (RECRUITING)
Study contacts
- Study coordinator: Xinbo Yu, BDS
- Email: xinboyu@proton.me
- Phone: 86+23271699
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Tooth Loss, ridge preservation, tooth extraction