Condition

Apical Periodontitis clinical trials and research

• 16Clinical trials
• 1NIH research projects
• 3New in 30 days
• 8Countries

Newest Apical Periodontitis clinical trials

All recruiting trials (16)

• Activation techniques in antimicrobial photodynamic therapy for retreatment of apical periodontitis

  This trial tests whether different methods of agitating methylene blue during antimicrobial photodynamic therapy can improve healing and reduce infection in teeth that prior root canals had treated for asymptomatic apical periodontitis.

  Recruiting Karadeniz Technical University · Trabzon, Ortahisar · NCT07921277

• Conventional and nano-metronidazole irrigation with or without ultrasonic activation for necrotic single-rooted teeth with apical periodontitis

  This study tests whether conventional metronidazole or a nano-formulated version, used as root canal irrigants with or without ultrasonic activation, can reduce post-operative pain and endotoxin levels in necrotic single-rooted teeth with apical periodontitis.

  Recruiting October 6 University · Giza, Giza Governorate · NCT07897591

• Post-operative Pain and Healing After Root Canal Re-Treatment Using Laser-Activated Irrigation vs Sonic or No Activation

  This study tests whether laser-activated irrigation or sonic activation helps reduce post-operative pain and improve healing after re-treating a tooth with persistent apical inflammation, compared to conventional needle irrigation.

  Recruiting at 2 sites University Ghent · Antwerp and 1 other locations · NCT07883486

• Different endodontic motor motions during root canals and their effect on pain

  This study tests whether using different apical motion modes on endodontic motors during root canal work changes postoperative pain in adults with chronic apical periodontitis.

  Recruiting Alanya Alaaddin Keykubat University · Antalya · NCT07714733

• Two irrigation methods and activation techniques during a single-visit retreatment: does pain differ after root canal retreatment?

  This study tests whether two different irrigation approaches and activation methods change postoperative pain after a single-visit retreatment in adults with a prior root canal.

  Recruiting Phase 4 TC Erciyes University · Kayseri · NCT07599254

• i-PRF regenerative treatment versus conventional non-surgical root canal retreatment for failed front teeth

  This trial will see if adding injectable platelet-rich fibrin (i-PRF) to regenerative treatment helps adults 18–50 with failed root canals and periapical lesions heal better than standard non-surgical retreatment.

  Recruiting Marmara University · Istanbul · NCT07448571

• How French dentists treat infected or non-vital baby (primary) teeth

  See how dentists in France treat children’s non-vital or infected primary teeth and what leads them to choose extraction, pulpectomy, or other options.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT07297836

• Comparing two medicines placed inside the root canal to help periapical lesions heal

  This study will test whether placing calcium hydroxide or diclofenac sodium inside the root canal helps periapical lesions heal in adults having retreatment of single-rooted lower teeth.

  Recruiting Mustafa Kemal University · Hatay, Antakya · NCT07237620

• Chitosan irrigation for mandibular premolar root canal treatment

  This test compares three common root-canal rinses to see which one best reduces bacteria in adults needing a premolar root canal.

  Recruiting Ordu University · Ordu, Altınordu · NCT07048028

• Measuring bite force to understand dental pain

  This study is testing how strong people's bite is when they have dental pain to see if it can help improve pain management and reduce the need for opioids during dental treatments.

  Recruiting Rutgers, The State University of New Jersey · Newark, New Jersey · NCT06843525

• Using light therapy to reduce pain and improve healing after dental surgery

  This study is testing whether light therapy can help reduce pain and speed up healing for people who have just had dental surgery.

  Recruiting The University of Texas Health Science Center, Houston · Houston, Texas · NCT06574152

• Evaluating healing after root-end surgery using L-PRF

  This study tests if using a special treatment called L-PRF during root-end surgery can help patients with ongoing tooth problems heal better and faster.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT06545084

• Revitalizing traumatized immature permanent teeth

  This study is testing how well revitalization treatments work for young permanent teeth that have been injured, with or without infection, to see if they can heal and develop properly over three years.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Ghent · NCT06043453

• Using dental MRI to diagnose jaw and tooth issues

  This study is testing whether a special type of MRI can better diagnose jaw and tooth problems compared to regular dental X-rays.

  Recruiting University of Aarhus · Aarhus · NCT05439330

• Assessing factors affecting root canal treatment outcomes

  This study looks at how different factors might affect the success of root canal treatments for patients receiving care in a specialist office in Slovenia.

  Recruiting Odontos, Specialisticna Zobna Ambulanta, d.o.o. · Ljubljana · NCT05221450

• Comparing one versus two visits for root canal treatments in infected teeth

  This study is testing whether getting a root canal treatment in one visit is just as effective as getting it in two visits for people with infected teeth.

  Recruiting at 4 sites Malmö University · Vaxjo, Kronoberg County and 6 other locations · NCT04605445

NIH-funded research (1)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Investigating how certain nerve cells affect pain relief in dental infections.

  This study is looking at how certain nerve cells can help relieve pain for people with a dental condition called apical periodontitis, and it’s exploring the use of human stem cells to see if they can make pain go away better than regular medications.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-10947075

Related topics

Quick answers

How many Apical Periodontitis clinical trials are recruiting right now?

16, as of November 12, 2026. 3 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in Turkey (Türkiye) (6 trials), United States (3 trials), Belgium (2 trials), France (1 trial), Sweden (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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