Effect of four post-extraction socket approaches on preserving the ridge after tooth removal
Official title: Comparative Efficacy of Three Alveolar Ridge Preservation Techniques for Volumetric Tissue Maintenance Following Tooth Extraction
Run by Universidad del Desarrollo · NCT07812883 · Data updated 2026-11-12
This study tests four ways to care for an extraction socket to see which best preserves the jawbone and gum after tooth removal for future implants.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 70 (estimated) |
| Sponsor | Universidad del Desarrollo Academic / other |
| Locations | 1 site (Santiago, Santiago Metropolitan) |
| Status | Recruiting |
| Started | September 15, 2026 |
| Main results expected | November 15, 2027 |
| Study ends | October 1, 2028 |
| Registry record updated | September 10, 2026 |
| Trial ID | NCT07812883 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18+ needing extraction with planned later implant-supported rehab in posterior jaws and good general health (ASA I–II).
✕Probably not a fit
Individuals with contraindications to extraction protocols or who do not require future implants may see no relevant benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized trial compares spontaneous healing, a d-PTFE membrane with a blood clot, a blood clot with L-PRF, and a blood clot with L-PRF plus d-PTFE membrane to determine which approach best maintains hard- and soft-tissue dimensions 12 weeks after extraction. It focuses on adults needing implant-supported rehabilitation in posterior regions and uses objective measurements of ridge preservation. Outcomes include healing, complications, pain, and bone regeneration. The study seeks to clarify the role of membranes and L-PRF in post-extraction socket management.
Why it matters
Potential benefit: If successful, the best approach could improve preservation of ridge dimensions, potentially simplifying implant placement and improving outcomes.
How similar studies have gone: Previous work has explored membranes and platelet concentrates, but direct head-to-head comparisons of these four approaches are limited and findings have been mixed.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 18 years or older. * Requirement for tooth extraction with the possibility of subsequent implant-supported rehabilitation in the maxillary or mandibular premolar or molar regions. * Extraction sockets classified as Class I to Class Va according to the modified Cardaropoli classification. * American Society of Anesthesiologists (ASA) Physical Status I or II. * Ability to understand the study procedures and provide written informed consent. Exclusion Criteria: * Current treatment with bisphosphonates or systemic corticosteroids. * History of head and neck radiotherapy. * Metabolic bone disorders. * Teeth presenting with acute infectious pathology at the time of extraction. * Pregnancy or breastfeeding. * Inability or unwillingness to attend scheduled follow-up visits. * Any medical or psychological condition that, in the opinion of the investigators, could interfere with study participation or data interpretation.
Where it's running
-
Universidad del Desarrollo (UDD)
Santiago, Santiago Metropolitan, Chile Recruiting
Study contacts
- Principal investigator: Claudio M Miranda, dds — Universidad del Desarrollo
- Study coordinator: Claudio M Claudio Miranda, DDS, Director
- Email: clmirandacar@gmail.com
- Phone: +56 (2) 2327 9110
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.