How losing teeth and wearing complete dentures affect taste, mouth sensations, and food preferences
Official title: Impact of Complete Tooth Loss and Denture on Oral Sensory Abilities and Food Preference
Run by Assistance Publique - Hôpitaux de Paris · NCT04281056 · Data updated 2026-11-12
We will test whether people who have lost all their teeth and wear complete dentures notice changes in taste, oral sensations, and food preferences compared with similar people who still have most of their natural teeth.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 79 Years |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Paris) |
| Status | Recruiting |
| Started | March 16, 2022 |
| Main results expected | April 2027 |
| Study ends | April 2027 |
| Registry record updated | December 19, 2025 |
| Trial ID | NCT04281056 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18–80 who are either completely edentulous and have worn clean, stable complete dentures during meals for at least one year, or matched dentate controls with at least 25 natural teeth and normal occlusion.
✕Probably not a fit
People under 18 or over 80, those with current dental or gum pain, or those unable to travel to the testing site are unlikely to benefit from participating.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This project compares 20 people who have been completely edentulous and wearing complete dentures for at least one year with 20 matched controls who have most of their natural teeth. Participants will undergo taste testing (electrogustometric thresholds and chemical taste identification), trigeminal quantitative sensory testing for oral somatosensory function, and standardized questionnaires on food preferences and taste appetence. Denture wearers must use their dentures during meals and have clean, stable prostheses, while controls must have at least 25 natural teeth and normal molar occlusion. All testing is conducted at the dental service of Hôpital Rothschild in Paris and excludes people under 18 or over 80 and those with recent dental or gum pain.
Why it matters
Potential benefit: If successful, the findings could help clinicians give better dietary guidance and denture-care recommendations to preserve or improve taste and eating enjoyment for people without teeth.
How similar studies have gone: Prior research has indicated that tooth loss can alter taste and food choices, but relatively few studies have combined electrogustometry, trigeminal quantitative sensory testing, and detailed food-preference measures in matched denture wearers, so this protocol is partly novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Study Group : being completely edentulous and wearing denture for at least one year, wearing denture during meals, with clean and stable dentures. Controls: controls Group : dentate subjects (25 teeth at leas, non endodontically treated) with molars in Angle's Class I occlusion, having no functional disturbance of mastication and not undergoing dental treatment at the time of the recording. Matched with subjects of the study group for age, sex, tabacco consumption, and saliva flow rate. Exclusion Criteria: * Aged under 18 or over 80 Y, * not consenting to participate * suffering from dental * periodontal or gum pain for the last month.
Where it's running
-
Service odontologie Hôpital Rothschild
Paris, France Recruiting
Study contacts
- Principal investigator: Adeline Braud, Doctor — Assistance Publique - Hôpitaux de Paris
- Study coordinator: Adeline Braud, Doctor
- Email: adeline.braud@aphp.fr
- Phone: 01 40 19 39 87
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.