Nobel N1 dental implant with early 6-week crown placement
Official title: Effects of Early Loading Protocol on the Survival of the Nobel N1 Implant System: A Pilot Randomized Controlled Trial
Run by Louisiana State University Health Sciences Center in New Orleans · NCT07280260 · Data updated 2026-11-12
This test will see if adults missing a single back tooth can get a final crown on a Nobel N1 dental implant 6 weeks after implant surgery.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Louisiana State University Health Sciences Center in New Orleans Academic / other |
| Drugs / interventions | Radiation |
| Locations | 1 site (New Orleans, Louisiana) |
| Status | Recruiting |
| Started | December 15, 2025 |
| Main results expected | December 31, 2027 |
| Study ends | January 30, 2028 |
| Registry record updated | August 27, 2026 |
| Trial ID | NCT07280260 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 or older who are generally healthy (ASA I–II), have a single missing posterior tooth with natural neighboring and opposing teeth, and can attend follow-up visits are the intended candidates.
✕Probably not a fit
Patients with conditions or medications that impair healing (for example uncontrolled diabetes, osteoporosis treatments, long-term corticosteroids), heavy smokers, pregnant or nursing individuals, or those unable to attend follow-ups are unlikely to benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults missing a single posterior tooth will receive a Nobel N1 implant using a protocol designed to minimize bone trauma. Participants will have their final crown placed at either 6 weeks or 12 weeks after implant placement and will be followed for one year. Outcomes include implant survival and measures of implant stability and function over the 12-month period. The Nobel N1 is an FDA-cleared design intended to promote faster integration and potentially allow earlier restoration than traditional protocols.
Why it matters
Potential benefit: If successful, patients could receive their permanent crown much sooner (around 6 weeks) and regain chewing function and appearance faster than with traditional timing.
How similar studies have gone: Early-loading protocols for dental implants have shown success in prior studies, but the Nobel N1 design and formal testing of a 6-week final crown timing are relatively new.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Males and females, age 18 or older * Can provide an Informed Consent in English. * Absence of a single posterior tooth in mandible or maxilla with presence of natural neighboring teeth (except for second molar which only requires presence of first molar) * Presence of antagonist teeth * Possibility and will for an immediate restoration. * Systemic health recorded as an American Society of Anesthesiologists (ASA) I or II Exclusion Criteria: * · Unavailability to attend the follow-up visits. * A systemic contraindication for oral surgical procedures; ASA III or IV. * Pregnancy or nursing on screening or before the surgical procedure. * Diseases that could alter healing or bone metabolism (uncontrolled diabetes, diagnostic osteoporosis, etc.), * Taking medications that are altering healing or bone metabolism (bisphosphonates, long-time corticosteroids intake, RANK inhibitors, etc.) * Alcohol or drug abuse. * Current heavy smoking behavior (≥10 cigarettes/day). * Radiation therapy to the head or neck region. * Pathology in the implant planned sites that prevent implant placement. * Current diagnosis of Diabetes, which is uncontrolled (\>7 HbA1C). * Need for sinus lift or vertical bone augmentation * Previously failed implant site
Where it's running
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LSU School of Dentistry
New Orleans, Louisiana, United States Recruiting
Study contacts
- Study coordinator: Amir Nejat
- Email: anejat@lsuhsc.edu
- Phone: 504-981-8283
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.