Autotransplantation of a patient's own tooth using simulated open apex and platelet-rich fibrin

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Autogenous tooth transplantation replaces a lost tooth with one of the patient's own teeth, preserving alveolar bone volume and periodontal proprioception. Teeth with complete root formation often fail to revascularize after transplantation, commonly resulting in pulp necrosis and the need for root canal treatment. This protocol combines instrumentally simulated apical patency with autologous platelet-rich fibrin (PRF) placed at the recipient site to promote pulpal revascularization and enhance tissue healing. Patients will undergo surgical transplantation with these adjuncts and be followed clinically and radiographically to compare rates of pulp necrosis and long-term success.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Autotransplantation will be performed in selected cases with favorable biological and functional prognosis, including:

* Early loss of permanent teeth due to trauma, extensive caries, or agenesis.
* Dental agenesis, particularly involving premolars or incisors, when a suitable donor tooth is available.
* Replacement of non-restorable teeth (fractures or destructive caries).
* Preservation of alveolar bone in growing patients where implant therapy is contraindicated.
* Functional and aesthetic rehabilitation of anterior teeth in pediatric and adolescent patients.
* Post-traumatic oral rehabilitation in young patients.
* Good general and oral health.
* Presence of a vital and intact periodontal ligament on the donor tooth.
* Adequate recipient site dimensions and morphology, or surgically adaptable.
* Absence of active infection at the recipient site. Donor Tooth Selection Criteria
* Tooth extracted for orthodontic purposes.
* Impacted or erupting third molars with compatible morphology.
* Suitable supernumerary teeth.

Exclusion Criteria:

* Poor patient compliance.
* Active infection at the recipient site.
* Smoking of more than 15 cigarettes a day

  •. Untreated periodontal disease
* Pregnancy or breastfeeding at date of inclusion
* Acute infections

Where it's running

• University of Bari Aldo Moro, Hospital
  Bari, Italy Recruiting

Study contacts

• Principal investigator: Giuseppe D'Albis, Dr. — University of Bari Aldo Moro
• Study coordinator: Giuseppe D'Albis, Dr.
• Email: giuseppe.dalbis@uniba.it
• Phone: +393495103642

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.