Comparing one versus two visits for root canal treatments in infected teeth

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to compare the outcomes of one-visit versus two-visit root canal treatments for infected teeth in general dental practice. It will assess the success rates, root filling quality, and complication frequencies of both treatment approaches one and four years after the procedures. A pilot study will first identify any protocol shortcomings, followed by a multi-center approach involving several clinics across five counties in Sweden. The study will include eligible patients with necrotic teeth and will require a sample size of 356 patients per treatment group to detect statistically significant differences.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient older than 17 years.
* Permanent tooth excluding third molars.
* Necrotic tooth with/without clinical and/or radiological signs of apical (juxta radicular) periodontitis (non-bleeding pulp in the canal orifice. In case of a multi rooted tooth, a non-bleeding pulp in at least one root canal orifice) where orthograde endodontic treatment is planned.

Exclusion Criteria:

* Patients with severe general disease and/ or where endodontic treatment requires special consideration for health reasons (eg radiation-treated jaw bone in the area or increased susceptibility to infection).
* Systemic involvement (fever).
* Swelling (extra- and/or intra oral).
* Previously root canal treated tooth (instrumented and/or rotfilled).
* Confirmed or strong suspicion of transverse or longitudinal root fracture.
* Trauma to the tooth (\<6 month).
* Marginal bone loss \>1/3 of the root lenght.
* Root resorption.
* Non restorable tooth.
* Endodontic treatment is not considered feasible because rubberdam cannot be used on the tooth.
* Follow-up at the clinic of the treatment after\> 1 year is considered not feasible.

Where it's running

• Folktandvården Region Kronoberg
  Vaxjo, Kronoberg County, Sweden Recruiting
• Folktandvården Region Norrbotten
  Luleå, Norrbotten County, Sweden Recruiting
• Smile Tandvård
  Luleå, Sweden Recruiting
• Folktandvården Region Halland
  Varberg, Sweden Recruiting
• Folktandvården Region Kalmar
  Kalmar, Sweden Not yet recruiting
• Aragón Dental
  Malmö, Sweden Not yet recruiting

Study contacts

• Study coordinator: Annika Björkner, PhD
• Email: annika.bjorkner@mau.se
• Phone: +46-(0)40-6658532

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Chitosan irrigation for mandibular premolar root canal treatment

  This test compares three common root-canal rinses to see which one best reduces bacteria in adults needing a premolar root canal.

  Recruiting Ordu University · Ordu, Altınordu · NCT07048028

• Activation techniques in antimicrobial photodynamic therapy for retreatment of apical periodontitis

  This trial tests whether different methods of agitating methylene blue during antimicrobial photodynamic therapy can improve healing and reduce infection in teeth that prior root canals had treated for asymptomatic apical periodontitis.

  Recruiting Karadeniz Technical University · Trabzon, Ortahisar · NCT07921277

• Conventional and nano-metronidazole irrigation with or without ultrasonic activation for necrotic single-rooted teeth with apical periodontitis

  This study tests whether conventional metronidazole or a nano-formulated version, used as root canal irrigants with or without ultrasonic activation, can reduce post-operative pain and endotoxin levels in necrotic single-rooted teeth with apical periodontitis.

  Recruiting October 6 University · Giza, Giza Governorate · NCT07897591

• Post-operative Pain and Healing After Root Canal Re-Treatment Using Laser-Activated Irrigation vs Sonic or No Activation

  This study tests whether laser-activated irrigation or sonic activation helps reduce post-operative pain and improve healing after re-treating a tooth with persistent apical inflammation, compared to conventional needle irrigation.

  Recruiting at 2 sites University Ghent · Antwerp and 1 other locations · NCT07883486

• Effect of four post-extraction socket approaches on preserving the ridge after tooth removal

  This study tests four ways to care for an extraction socket to see which best preserves the jawbone and gum after tooth removal for future implants.

  Recruiting Universidad del Desarrollo · Santiago, Santiago Metropolitan · NCT07812883

• Immediate molar implants with customized healing abutments in different socket classes

  This study tests placing an implant right after extracting a back tooth and using a custom healing cap to shape the gum from day one, in people needing posterior implants.

  Recruiting Plovdiv Medical University · Plovdiv · NCT07801573

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.