Condition

Thoracic Aortic Aneurysm clinical trials and research

• 13Clinical trials
• 11NIH research projects
• 12Countries

Newest Thoracic Aortic Aneurysm clinical trials

All recruiting trials (13)

• GORE MBA Arch Endoprosthesis Early Feasibility Study

  This study tests the safety of the MBA device in people with arch-related thoracic aortic diseases to see if it can be used safely in real-world settings.

  Recruiting at 3 sites W.L.Gore & Associates · Los Angeles, California and 2 other locations · NCT07564375

• See if spironolactone can reduce aortic stiffness in adults with thoracic aortic aneurysm

  This study tests whether spironolactone reduces aortic stiffness compared with placebo in adults with degenerative thoracic aortic aneurysms.

  Recruiting Phase 1/2 Mayo Clinic · Rochester, Minnesota · NCT07483177

• Evaluating outcomes of thoracic aortic repair in patients with compromised landing zones

  This study is testing different stent-graft options for patients with aortic aneurysms who have tricky anatomy to see if they can prevent complications after surgery.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma, RM · NCT06882967

• Advancing genomic medicine using electronic health records

  This study is trying to see if using electronic health records and helpful reminders can get more patients tested for genetic conditions in a way that doctors can easily use.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT06377033

• Exploring genetic factors in acute aortic conditions

  This study is testing whether looking at the genes of people with aortic dissection or aneurysm can help doctors better predict who is at risk and improve their chances of getting timely treatment.

  Recruiting University Hospital, Basel, Switzerland · Basel · NCT06353607

• Using presepsin levels to guide antibiotic treatment in thoracic aorta surgery patients

  This study is testing if measuring a specific marker in the blood can help doctors give the right antibiotics to patients after thoracic aorta surgery to prevent infections and improve recovery.

  Recruiting Petrovsky National Research Centre of Surgery · Moscow, Moscow · NCT06336213

• Evaluating outcomes of custom-made aortic devices

  This study looks at how well custom-made aortic devices work for people with thoracic aortic disease after they've had a specific repair procedure.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma, RM · NCT05777460

• Assessing major complications in patients with thoracic aortic aneurysm

  This study is trying to see how often serious problems happen in people with small to moderate thoracic aortic aneurysms over five years and what factors might affect their condition.

  Recruiting University Hospital, Lille · Lille, Please Choose... · NCT05395598

• Endovascular treatment for aortic arch pathologies in Spain

  This study is testing if special stent devices can help people aged 18 to 90 with serious aortic arch problems live longer and stay safe.

  Recruiting Vascular Investigation Network Spanish Society for Angiology and Vascular Surgery · Madrid · NCT05309707

• New technique for repairing thoracic aortic conditions

  This study is testing a new method to repair certain serious aortic conditions in patients by using a special type of stent to see if it is safe and effective.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT04747626

• Analyzing neuroinflammatory markers in cerebrospinal fluid before and after thoracic aortic surgery

  This study is trying to see how levels of certain proteins in the fluid around the brain change before and after thoracic aortic surgery to better understand why some patients experience confusion or memory problems afterward.

  Recruiting Radboud University Medical Center · Nijmegen · NCT04523909

• Registry for safety and performance of Terumo Aortic endovascular grafts

  This study is collecting information from patients with abdominal and thoracic aortic aneurysms to see how safe and effective Terumo Aortic stent-grafts are in real-life use.

  Recruiting at 50 sites Vascutek Ltd. · Long Beach, California and 57 other locations · NCT04246463

• Exercise and blood pressure in people with thoracic aortic aneurysm

  This trial will test whether a supervised moderate-to-high intensity aerobic exercise program changes blood pressure responses in adults with thoracic aortic aneurysm.

  Recruiting Laval University · Québec, Quebec and 1 other locations · NCT04197648

NIH-funded research (11)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Biomarker clues from animal and computer models to predict when the ascending aorta could fail

  Researchers will combine animal studies and computer models to find biological clues that help predict dangerous changes in the ascending aorta for people with aortic aneurysm.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11465647

• Sexual differences in thoracic aortic aneurysm biology

  A study to understand why men and women experience thoracic aortic aneurysms differently, with a focus on human tissue and biology.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11406202

• Using AI and 3D CT scans to predict rupture risk for thoracic aortic aneurysms

  This project uses machine learning plus 3D CT scans to help identify adults with thoracic aortic aneurysms—especially smaller ones—who may be at higher risk of rupture.

  NIH research University of Miami Coral Gables · Coral Gables, United States · NIH-11260144

• Understanding the causes and treatments for thoracic aortic aneurysm

  This study is looking into how thoracic aortic aneurysms develop in people with Marfan syndrome, with the goal of finding new ways to treat this condition, and it involves testing different medications on animal models to see how they affect aortic health.

  NIH research University of Kentucky · Lexington, United States · NIH-11136787

• Finding better warning signs for problems in the upper aorta (ascending aortic aneurysm)

  Researchers are combining mouse experiments, computer simulations, and patient scans to find sets of markers that could warn people with ascending aortic aneurysms about the risk of rapid growth, tearing, or rupture.

  NIH research Washington University · Saint Louis, United States · NIH-11117068

• Understanding how biomechanical factors affect the growth and rupture of aortic aneurysms

  This study is looking at how certain physical changes in the aorta can help us understand why some aortic aneurysms grow or tear, specifically in veterans, so we can improve how we decide when surgery is needed.

  NIH research Veterans Affairs Med Ctr San Francisco · San Francisco, United States · NIH-11073101

• Understanding how fat tissue around blood vessels affects aortic aneurysms

  This study is looking at how the fat around blood vessels might affect the development of thoracic aortic aneurysms, a serious condition, and aims to find new ways to prevent or treat it, with the help of patients who can share tissue samples or participate in related studies.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11064805

• Identifying biomarkers for aortic aneurysm using animal and computer models

  This study is looking for new ways to predict how an ascending thoracic aortic aneurysm (ATAA) might grow or become dangerous, using special mice models and advanced computer techniques, to help doctors make better decisions about when to recommend surgery for patients like you.

  NIH research Washington University · Saint Louis, United States · NIH-11063400

• Understanding the causes and treatments for thoracic aortic aneurysm

  This study is looking into how thoracic aortic aneurysms develop in people with Marfan syndrome, with the goal of finding new ways to treat this condition, and it's being led by Dr. Mary Sheppard at the University of Kentucky.

  NIH research University of Kentucky · Lexington, United States · NIH-11003314

• Using machine learning to assess the risk of thoracic aortic aneurysm rupture

  This study is looking at how advanced computer technology can help doctors better understand the risk of smaller thoracic aortic aneurysms bursting, so they can identify patients who might need surgery sooner.

  NIH research University of Miami Coral Gables · Coral Gables, United States · NIH-10993130

• Identifying biomarkers for aortic aneurysm using animal and computer models

  This study is looking for new ways to predict how an ascending thoracic aortic aneurysm might grow or cause problems, using special mouse models and patient imaging, to help doctors make better decisions for people with this serious heart condition.

  NIH research Washington University · Saint Louis, United States · NIH-10862732

Related topics

Quick answers

How many Thoracic Aortic Aneurysm clinical trials are recruiting right now?

13, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in United States (5 trials), Italy (3 trials), France (2 trials), Netherlands (2 trials), Spain (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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