Identifying biomarkers for aortic aneurysm using animal and computer models
Complementary animal and computational models for biomarker identification in ascending thoracic aortic aneurysm
This study is looking for new ways to predict how an ascending thoracic aortic aneurysm (ATAA) might grow or become dangerous, using special mice models and advanced computer techniques, to help doctors make better decisions about when to recommend surgery for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11063400 on NIH RePORTER |
What this research studies
This research investigates the ascending thoracic aortic aneurysm (ATAA), a serious cardiovascular condition where the aorta is dilated and at risk of rupture. The study aims to identify new biomarkers that can predict the growth and failure of ATAA by utilizing a combination of animal models, specifically mice with Marfan Syndrome, and advanced computational models based on real patient imaging data. By integrating genetic, structural, and fluid-based data, the research seeks to develop composite biomarkers that provide better predictions than current methods, which rely primarily on aorta diameter and growth rate. This innovative approach could lead to improved criteria for surgical intervention, potentially saving lives.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with ascending thoracic aortic aneurysm, particularly those with genetic predispositions such as Marfan Syndrome.
Not a fit: Patients without a diagnosis of ascending thoracic aortic aneurysm or those who do not have genetic conditions associated with aortic aneurysms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate identification of patients at risk for aortic aneurysm rupture, improving surgical outcomes.
How similar studies have performed: Previous research has shown promise in using animal models and computational approaches to identify biomarkers in other cardiovascular conditions, suggesting potential success for this novel approach.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Wagenseil, Jessica — Washington University
- Study coordinator: Wagenseil, Jessica
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.