Understanding how biomechanical factors affect the growth and rupture of aortic aneurysms
Developing Biomechanical Predictors of Ascending Thoracic Aortic Aneurysm Growth and Dissection
This study is looking at how certain physical changes in the aorta can help us understand why some aortic aneurysms grow or tear, specifically in veterans, so we can improve how we decide when surgery is needed.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Affairs Med Ctr San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11073101 on NIH RePORTER |
What this research studies
This research investigates the biomechanical predictors of ascending thoracic aortic aneurysm (aTAA) growth and dissection using advanced imaging techniques. By employing 4D flow magnetic resonance imaging (MRI), the study aims to evaluate changes in wall stresses and distensibility of aTAAs in veterans. The goal is to improve current surgical guidelines that rely primarily on aneurysm diameter, which may not accurately predict dissection or rupture. This approach could lead to better risk assessment and management for patients with aTAAs.
Who could benefit from this research
Good fit: Ideal candidates for this research are veterans diagnosed with ascending thoracic aortic aneurysms that do not currently meet surgical intervention criteria.
Not a fit: Patients with aortic aneurysms that are already indicated for surgery or those without access to the Veterans Affairs healthcare system may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate predictions of aortic aneurysm complications, potentially saving lives and improving surgical outcomes.
How similar studies have performed: Previous studies have indicated that biomechanical factors can significantly influence aortic aneurysm outcomes, suggesting that this approach may yield valuable insights.
Where this research is happening
San Francisco, United States
- Veterans Affairs Med Ctr San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Tseng, Elaine Evelina — Veterans Affairs Med Ctr San Francisco
- Study coordinator: Tseng, Elaine Evelina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.