Identifying biomarkers for aortic aneurysm using animal and computer models
Complementary animal and computational models for biomarker identification in ascending thoracic aortic aneurysm
['FUNDING_R01'] · WASHINGTON UNIVERSITY · NIH-10862732
This study is looking for new ways to predict how an ascending thoracic aortic aneurysm might grow or cause problems, using special mouse models and patient imaging, to help doctors make better decisions for people with this serious heart condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-10862732 on ClinicalTrials.gov |
What this research studies
This research investigates the ascending thoracic aortic aneurysm (ATAA), a serious cardiovascular condition where the aorta is dilated and at risk of dissection or rupture. The study aims to identify new biomarkers that can predict the growth and failure of ATAA by utilizing a combination of animal models, specifically a mouse model associated with Marfan Syndrome, and advanced computational models based on real patient imaging data. By analyzing genetic, microstructural, and geometrical factors, the research seeks to develop composite biomarkers that provide better predictions for patient outcomes than current methods. This approach addresses the limitations of existing surgical guidelines, which often fail to prevent dissections in patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with ascending thoracic aortic aneurysm, particularly those with genetic predispositions such as Marfan Syndrome.
Not a fit: Patients without a diagnosis of ascending thoracic aortic aneurysm or those who are not genetically predisposed may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for predicting aneurysm failure, potentially saving lives by enabling timely surgical interventions.
How similar studies have performed: Other research has shown promise in using animal and computational models to identify biomarkers for various conditions, suggesting that this approach could yield valuable insights for ATAA as well.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WAGENSEIL, JESSICA — WASHINGTON UNIVERSITY
- Study coordinator: WAGENSEIL, JESSICA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.