Analyzing neuroinflammatory markers in cerebrospinal fluid before and after thoracic aortic surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational pilot study aims to investigate the changes in neuroinflammatory protein levels in cerebrospinal fluid (CSF) in patients undergoing thoracic aortic surgery. Patients will have an external lumbar drain placed before surgery, allowing for the collection of paired CSF and blood samples. The study seeks to understand the biochemical pathways involved in postoperative delirium and cognitive dysfunction by analyzing these samples before and after the surgical procedure. The findings may provide insights into the relationship between systemic inflammation and neuroinflammation following major surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Competent patients ≥ 18 years
* Patients who will undergo thoracic aortic surgery and will therefore receive an external lumbar drain as a standard of care procedure.

Exclusion Criteria:

* Patients with meningitis/encephalitis/brain abscess within the last 6 months
* Patients with other neurological conditions: brain injury (acute stroke, brain trauma or cerebral haemorrhage) within the last 3 months, known brain tumours, neurodegenerative disease or known pre-existing cognitive impairment (to a degree that would be compatible with mild cognitive impairment or more).
* Brain or spinal surgery within the last 3 months
* Active infection \<2 weeks before surgery
* Patients who object against storage of their body material for scientific reasons

Where it's running

• Department of Intensive Care Medicine, Radboud university medical center
  Nijmegen, Netherlands Recruiting

Study contacts

• Study coordinator: Wilson F. Abdo, MD, PhD
• Email: f.abdo@radboudumc.nl
• Phone: +31243617273

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.