Exploring genetic factors in acute aortic conditions

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the genetic information linked to acute aortic dissection and thoracic aortic aneurysm in individuals without a history of syndromic features. Whole genome sequencing will be performed on patients who have documented cases of aortic aneurysm or dissection. The study seeks to improve risk prediction tools for identifying high-risk patients, which could lead to timely diagnosis and surgical intervention, ultimately reducing morbidity and mortality associated with these conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* All adult patients \> 18 years who underwent surgery for aAD or TAA intervention at the University Hospital Basel, starting in 2015.
* All patients who will undergo surgery for aAD or TAA at the University Hospital Basel, beginning in 2024.

Exclusion Criteria:

* Patients will be excluded if they are not able or not willing to provide informed consent.
* Patients with diagnosed heritable vascular disorders, such as Marfan syndrome, Turner Syndrome, Loeyes Dietz and Ehlers-Danlos syndrome.

Where it's running

• University Hospital Basel
  Basel, Switzerland Recruiting

Study contacts

• Principal investigator: Denis Berdajs, Prof. Dr. — University Hospital, Basel, Switzerland
• Study coordinator: Denis Berdajs, Prof. Dr.
• Email: denis.berdajs@usb.ch
• Phone: 0041 61 328 71 80

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Evaluating outcomes of thoracic aortic repair in patients with compromised landing zones

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• Advancing genomic medicine using electronic health records

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• Using presepsin levels to guide antibiotic treatment in thoracic aorta surgery patients

  This study is testing if measuring a specific marker in the blood can help doctors give the right antibiotics to patients after thoracic aorta surgery to prevent infections and improve recovery.

  Recruiting Petrovsky National Research Centre of Surgery · Moscow, Moscow · NCT06336213

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.