Using presepsin levels to guide antibiotic treatment in thoracic aorta surgery patients
Changes in Antibacterial Therapy Based on Perioperative Dynamics of Presepsin During Reconstructive Thoracic Aorta Surgery
NA · Petrovsky National Research Centre of Surgery · NCT06336213
This study is testing if measuring a specific marker in the blood can help doctors give the right antibiotics to patients after thoracic aorta surgery to prevent infections and improve recovery.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | Petrovsky National Research Centre of Surgery (other) |
| Locations | 1 site (Moscow, Moscow) |
| Trial ID | NCT06336213 on ClinicalTrials.gov |
What this trial studies
This study investigates the use of presepsin, a biomarker, to predict and manage postoperative complications in patients undergoing thoracic aorta surgery. By monitoring presepsin levels, the study aims to identify patients at risk for infections and adjust antibiotic therapy accordingly, specifically administering ampicillin/sulbactam if necessary. The research builds on previous findings that link presepsin levels to postoperative outcomes, with the goal of improving patient care and reducing complications. The study will evaluate the effectiveness of this tailored approach in enhancing recovery and minimizing inflammatory issues post-surgery.
Who should consider this trial
Good fit: Ideal candidates for this study are patients diagnosed with thoracic aorta aneurysm or dissection.
Not a fit: Patients with hemolysis in their blood samples will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce postoperative infections and improve recovery outcomes for patients undergoing thoracic aorta surgery.
How similar studies have performed: Previous studies have shown promising results using biomarkers like presepsin to predict complications in cardiac surgery, suggesting this approach may be effective.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Thoracic aorta aneurysm/dissection Exclusion Criteria: Blood sample hemolysis
Where this trial is running
Moscow, Moscow
- Petrovsky Research National Centre of Surgery (Petrovsky NRCS) — Moscow, Moscow, Russia (RECRUITING)
Study contacts
- Principal investigator: Boris Akselrod, Professor — Petrovsky NRCS
- Study coordinator: Artem Gubko, Ph.D.
- Email: gubko@artvig.ru
- Phone: +79684241490
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Aortic Aneurysm and Dissection, Cardiac Valve Disease, Thoracic Aortic Aneurysm, Thoracic Aortic Dissection, biomarkers, presepsin, complications, aortic arch