Condition
Solid Tumor, Adult clinical trials and research
As of November 12, 2026, Find a Trial lists 76 Solid Tumor, Adult clinical trials that are recruiting, at sites in 22 countries (most in United States (45), China (22), Australia (10)). By phase: Phase 1 (29), Phase 1/2 (27), Phase 2 (5), Phase 2/3 (2). The most active sponsors are Second Affiliated Hospital of Guangzhou Medical University (10), A2 Biotherapeutics Inc. (3), Gustave Roussy, Cancer Campus, Grand Paris (2). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 76Clinical trials
- 22Countries
Newest Solid Tumor, Adult clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| HMPL-A830 in solid tumors for adults with unresectable or metastatic cancer | Phase 1/2 | Orange, California and 13 other locations | Recruiting | Jul 22, 2026 |
| Imaging with 89Zr-DFO-YS5 to detect cancer | Phase 1 | San Francisco, California | Recruiting | Jun 24, 2026 |
| DESCANSO/REST mental health program for Spanish-speaking Latino adults with cancer experiencing depression, insomnia, and fatigue | — | Basking Ridge, New Jersey and 7 other locations | Recruiting | Nov 5, 2025 |
| Personalized PULSAR radiotherapy for advanced small cell lung cancer and brain metastases | Phase 1 | Dallas, Texas | Recruiting | Aug 24, 2025 |
| VS-7375 for adults with KRAS G12D-mutated advanced solid tumors. | Phase 1/2 | Los Angeles, California and 21 other locations | Recruiting | Jun 13, 2025 |
| Using a modified cold virus to treat certain solid tumors | Phase 1/2 | Barcelona and 7 other locations | Recruiting | May 18, 2025 |
| BBO-11818 treatment for adults with KRAS mutant cancer | Phase 1 | Los Angeles, California and 16 other locations | Recruiting | Apr 8, 2025 |
| Evaluating TYRA-430 for advanced liver and solid tumors with specific genetic changes | Phase 1 | Los Angeles, California and 15 other locations | Recruiting | Apr 8, 2025 |
| Evaluating AD1208 for advanced solid tumors | Phase 1/2 | Seongnam-si, Gyeonggi-do and 2 other locations | Recruiting | Apr 4, 2025 |
| Combining Pazopanib and Palbociclib for Hard-to-Treat Solid Tumors | Phase 1/2 | Tianjin, Tianjin Municipality | Recruiting | Mar 26, 2025 |
All recruiting trials (76)
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HMPL-A830 in solid tumors for adults with unresectable or metastatic cancer
This first-in-human study tests HMPL-A830 in adults with unresectable or metastatic solid tumors to see how safe it is and how it behaves at varying doses.
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Imaging with 89Zr-DFO-YS5 to detect cancer
This study tests a new PET radiotracer, 89Zr-DFO-YS5, to see if it can show cancer sites in adults with nerve sheath tumors, bladder cancer, or other solid tumors.
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DESCANSO/REST mental health program for Spanish-speaking Latino adults with cancer experiencing depression, insomnia, and fatigue
This program will test whether a telehealth-delivered DESCANSO/REST intervention can help Spanish-speaking Latino adults with stage I–III solid tumors who are receiving systemic cancer treatment feel less depressed, sleep better, and have less fatigue.
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Personalized PULSAR radiotherapy for advanced small cell lung cancer and brain metastases
This trial will try personalized PULSAR radiotherapy schedules to see if they are safe and helpful for adults with extensive-stage small cell lung cancer who need thoracic radiation and for adults with 1–5 brain metastases.
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VS-7375 for adults with KRAS G12D-mutated advanced solid tumors.
This trial tests VS-7375, alone and combined with other cancer drugs, in adults with unresectable or metastatic solid tumors that have the KRAS G12D mutation.
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Using a modified cold virus to treat certain solid tumors
This study is testing a new treatment made from a modified cold virus to see if it can safely target and help people with certain types of solid tumors.
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BBO-11818 treatment for adults with KRAS mutant cancer
This study is testing a new drug called BBO-11818 to see if it can help adults with certain types of cancer that have specific KRAS mutations.
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Evaluating TYRA-430 for advanced liver and solid tumors with specific genetic changes
This study is testing a new drug called TYRA-430 to see if it can help people with advanced liver and other solid tumors that have certain genetic changes.
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Evaluating AD1208 for advanced solid tumors
This study is testing a new drug called AD1208 to see if it is safe and tolerable for people with advanced solid tumors.
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Combining Pazopanib and Palbociclib for Hard-to-Treat Solid Tumors
This study is testing a new combination of two drugs, Pazopanib and Palbociclib, to see if it can help people with hard-to-treat solid tumors that have certain genetic changes.
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IntraTumor T-Cell Boost with Dual Immune Checkpoint Inhibitors in ARID1A-Mutated Esophageal/Gastric Adenocarcinoma
A first-in-human test of a single-dose combination of tremelimumab and durvalumab in adults with ARID1A-mutated, non-metastatic esophageal, GEJ, or stomach adenocarcinoma to see if it can increase tumor T cells.
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Evaluating a new CAR T-cell therapy for solid tumors expressing EGFR
This study is testing a new CAR T-cell therapy to see if it can safely help adults with certain solid tumors, like colorectal and lung cancer, that have specific markers.
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Evaluating BBO-10203 for advanced solid tumors
This study is testing a new treatment called BBO-10203, alone and with another drug, to see if it can help people with advanced solid tumors, including certain types of breast cancer.
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Testing EGL-001 in patients with advanced solid tumors
This study is testing a new treatment called EGL-001 for people with advanced solid tumors to see how well it works and what the best dose is.
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Effect of CT3001 on Advanced Solid Tumors
This study is testing a new treatment called CT3001 to see if it can help people with advanced solid tumors, like colorectal cancer and pancreatic cancer, who haven't responded to other therapies.
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Evaluating NKT3964 for Adults with Advanced Solid Tumors
This study is testing a new drug called NKT3964 to see if it can safely help adults with advanced solid tumors, like ovarian or triple-negative breast cancer, after other treatments have failed.
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Testing DB-1419 for advanced solid tumors
This study is testing a new drug called DB-1419 to see if it can help adults with advanced solid tumors that can't be surgically removed and haven't responded to other treatments.
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Testing KLS-1 for treating certain cancers
This study is testing a new drug called KLS-1 to see if it can safely help adults with certain types of cancer, including solid tumors and chronic lymphocytic leukemia.
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Software-guided immunotherapy for advanced solid tumors
This study is testing a new AI software that suggests a mix of immunotherapy drugs for people with advanced solid tumors, like lung and liver cancers, to see if it helps them respond better to treatment while reducing side effects.
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Vaccination using immune cells to treat solid tumors
This study is testing a new vaccine made from immune cells to see if it can help people with advanced solid tumors fight their cancer safely.
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Testing CX-801 for advanced solid tumors
This study is testing a new treatment called CX-801, alone and with another drug, to see if it can help adults with advanced solid tumors feel better and fight their cancer.
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Treatment of advanced solid tumors with VET3-TGI immunotherapy
This study is testing a new cancer treatment called VET3-TGI to see if it can safely target and kill cancer cells in patients with advanced solid tumors, either by injecting it directly into the tumors or giving it through an IV.
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Combining radiation therapy with ATRA for treating oligo-metastatic solid cancers
This study is testing whether combining a specific type of radiation therapy with a medication called ATRA can help people with certain solid cancers that have spread to a few places in the body.
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Improving genetic testing for cancer patients through nurse-led support
This study is testing if support from oncology nurses can help adult cancer patients get better access to genetic testing and counseling to improve their treatment options.
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R-5780 with PD-1 blockers for adults with advanced melanoma and other solid tumors
This Phase 1 test will try an oral probiotic called R-5780 together with PD-1 checkpoint inhibitors to see if adults with advanced solid tumors can tolerate it safely.
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Using GT307 injection to treat solid tumors
This study is testing a new injection called GT307 to see if it can safely help people with advanced solid tumors feel better.
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Patritumab deruxtecan for solid tumors with NRG1 fusion
This study is testing a new treatment called patritumab deruxtecan to see if it helps people with solid tumors that have a specific genetic change known as an NRG1 fusion.
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Creating personalized cancer models using patient samples
This study is trying to create personalized cancer models using samples from patients with solid tumors to help find better treatments for cancer.
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Investigating NST-628 Oral Tablets for Patients with Solid Tumors
This study is testing a new oral medication called NST-628 to see if it can safely help adults with advanced solid tumors that have specific genetic mutations.
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Using fluorescent imaging agents to improve tumor removal during surgery
This study is testing a new way to help surgeons see and remove all of the cancer during surgery by using special fluorescent dyes that highlight tumor tissue.
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Investigating CRB-701 for treating solid tumors
This study is testing a new treatment called CRB-701 to see if it can safely help people with advanced solid tumors that have a specific protein called nectin-4.
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Testing CX-2051 for advanced solid tumors
This study is testing a new drug called CX-2051 to see if it is safe and effective for adults with advanced solid tumors.
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Evaluating FMC-376 for advanced solid tumors with KRAS G12C mutations
This study is testing a new drug called FMC-376 to see if it can help people with advanced solid tumors that have a specific KRAS G12C mutation.
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Treatment of advanced lung cancer using KB707
This study is testing a new treatment called KB707 to see if it can help adults with advanced lung cancer by boosting their immune response, especially for those who haven't had success with standard therapies.
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T cell therapy targeting KRAS G12D in advanced solid tumors
This trial will test whether autologous T cells engineered to recognize KRAS G12D can help adults with unresectable or metastatic solid tumors who have the matching HLA type.
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CAR-γδT cell therapy targeting GPC3 and Mesothelin for cancer treatment
This study is testing a new cancer treatment that uses modified immune cells to target specific proteins in patients with advanced solid tumors.
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mRNA vaccine for treating solid tumors
This study is testing a new mRNA vaccine for people with advanced solid tumors to see if it can safely help their bodies fight cancer.
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Vaccine to treat solid tumors using neoantigens
This study is testing a personalized vaccine made from cancer markers to see if it can help people with advanced solid tumors feel better and improve their treatment outcomes.
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Evaluating ABO2011 for advanced solid tumors
This study is testing a new treatment called ABO2011, alone or with another drug, to see if it can help people with advanced solid tumors feel better and improve their health.
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Evaluating a new CAR T-cell therapy for solid tumors expressing MSLN
This study is testing a new CAR T-cell therapy to see if it can safely treat adults with solid tumors like colorectal and lung cancer that express a specific protein.
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Combining cryoablation with Tislelizumab and Lenvatinib for treating solid tumors
This study is testing a new treatment that combines freezing therapy with two drugs, Tislelizumab and Lenvatinib, to see if it helps people with solid tumors who have already received other treatments.
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Treatment for recurrent and refractory solid tumors using IMA402
This study is testing a new treatment called IMA402 to see if it can help people with advanced solid tumors that haven't responded to other therapies.
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Palliative care led by clinical nurse specialists for patients with advanced cancer
This study is testing if having a specialized nurse-led team for palliative care can help adults with advanced cancer feel better and live longer compared to regular care.
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CD70 targeted CAR-T cell therapy for advanced solid tumors
This study is testing a new type of CAR-T cell therapy that targets CD70 to see if it can help people with advanced solid tumors feel better and improve their treatment outcomes.
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Using a radiotracer to detect granzyme B in advanced cancers
This study is testing a new imaging tool to see if it can help find specific markers in advanced cancers, especially in patients with kidney and prostate cancer, to better understand how their tumors respond to treatment.
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Platform program for evaluating treatments in metastatic HER2-positive breast cancer
This study is testing different new treatments for people with advanced HER2-positive breast cancer to see which ones work best before moving them to larger trials.
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Combining two treatments for patients with certain solid tumors
This study is testing if combining a radioactive treatment with another drug can help people with certain solid tumors, like advanced kidney cancer, feel better and improve their condition.
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Evaluating a new treatment for advanced solid tumors
This study is testing a new treatment called ADU-1805 for people with advanced solid tumors to see how safe it is and how well it works on its own and with another drug.
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CAR-T cell therapy targeting mesothelin for cancer treatment
This study is testing a new CAR-T cell therapy that targets a specific protein in advanced cancers, like pancreatic cancer, to see if it can help patients feel better and fight their disease.
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AK119 plus AK112 for advanced solid tumors
This trial tests whether combining two experimental drugs, AK119 and AK112, is safe and may help adults with advanced solid tumors that have progressed after standard treatment.
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GV20-0251 treatment for advanced solid tumors
This study is testing a new treatment called GV20-0251 for people with advanced solid tumors that haven't improved with standard treatments, to see how safe it is and if it works better when combined with another medication.
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Combination of CAR-DC Vaccine and Immune Checkpoint Inhibitors for Treating Malignant Tumors
This study is testing a new vaccine combined with immune treatments to see if it can help people with advanced tumors and certain types of lymphomas fight their cancer better.
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Exploring immune responses to cell therapy in tumors
This study is testing how the immune system reacts to a new cell therapy in patients with different types of tumors to see if these reactions can help predict how well the treatment works and what side effects might occur.
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Creating a database for patients treated with immunotherapy for solid tumors
This study is creating a database to track how well immunotherapy works and its side effects in patients with solid tumors over five years.
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Testing a new drug for advanced solid tumors and breast cancer with specific mutations
This study is testing a new drug called RLY-2608 to see if it can help people with advanced solid tumors and breast cancer that have specific mutations.
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Evaluating the safety and tolerability of TRE-515 in patients with solid tumors
This study is testing a new oral medication called TRE-515 to see if it is safe and tolerable for people with advanced solid tumors.
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Combination therapy for advanced solid tumors and prostate cancer
This study is testing a new combination of five oral drugs to see if they can safely help people with advanced solid tumors and prostate cancer.
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Analyzing solid tumors for HLA loss and collecting T cells for CAR T-cell therapy
This study is testing how often solid tumors lose a key protein that helps the immune system recognize them, while also collecting T cells from patients with high-risk cancers to prepare for future CAR T-cell therapy.
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Adapting a communication program for Latinx cancer patients
This study is testing a new communication program to help Spanish-speaking cancer patients in the Bronx talk about their health values with their nurses.
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Evaluating KIN-2787 for patients with specific tumor mutations
This study is testing a new drug called KIN-2787 to see if it can help adults with advanced cancers that have certain gene mutations, like those found in lung cancer and melanoma.
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Engineered TILs and CAR-TILs for treating advanced solid tumors
This study is testing a new way to treat advanced solid tumors by using specially modified immune cells from patients to see if they can better fight the cancer.
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Combination treatment for advanced solid tumors using Trametinib, Everolimus, and Lenvatinib
This study is testing a new combination of three drugs to see if it can help people with advanced solid tumors, like liver cancer, feel better and improve their condition.
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Injection of drug-eluting microspheres into tumors
This study tests if injecting tiny drug-filled beads directly into advanced tumors can safely help people with cancer feel better and improve their treatment outcomes.
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Evaluating VT3989 for patients with metastatic solid tumors
This study is testing a new drug called VT3989 to see if it can help people with hard-to-treat metastatic solid tumors, including mesothelioma, feel better and fight their cancer.
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INV-1120 alone and with pembrolizumab for adults with advanced solid tumors
This Phase 1 study will test whether the experimental drug INV-1120, given alone or with pembrolizumab, is safe and tolerable in adults with advanced solid tumors who have progressed after standard therapies.
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Evaluating HMPL-453 for advanced intrahepatic cholangiocarcinoma
This study is testing a new drug called HMPL-453 to see if it helps people with advanced bile duct cancer that has specific genetic changes.
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Combining BI-1206 with Pembrolizumab for Advanced Solid Tumors
This study is testing a new combination of two treatments, BI-1206 and pembrolizumab, to see if it can help people with advanced solid tumors who have already tried other therapies.
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Testing BP1001-A for advanced or recurrent solid tumors
This study is testing a new drug called BP1001-A to see if it can safely help people with advanced or recurring solid tumors when used alone or with another medication called paclitaxel.
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Treatment for advanced solid tumors using PD-1 blockade and chemoradiotherapy
This study is testing if a new drug combined with standard chemotherapy and radiation can help people with advanced solid tumors feel better and improve their treatment outcomes.
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Real-time imaging of tumor blood vessels during surgery
We will test whether a real-time microscope technique during surgery can show how well blood vessels in adults' solid tumors work and whether that helps predict if systemic cancer medicines can reach the tumor.
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TCR-T cell immunotherapy for lung cancer and solid tumors
This study is testing a new immunotherapy that uses specially modified T cells to see if it can help people with advanced lung cancer and other solid tumors.
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AZD5363 with olaparib and durvalumab for advanced or metastatic solid tumors
This trial tries giving AZD5363 together with olaparib and durvalumab to adults with advanced or metastatic solid tumors to see if the combination is safe and to find a tolerable dose.
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Treatment for recurrent and refractory solid tumors using engineered T-cells and nivolumab
This study is testing a new treatment using specially designed T-cells and a drug called nivolumab to see if it can help people with tough-to-treat solid tumors.
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Testing HQP1351 for GIST and other solid tumors
This study is testing a new drug called HQP1351 to see if it can help people with gastrointestinal stromal tumors and other solid tumors feel better and how much of the drug is safe to use.
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Using Nivolumab after Half-Matched Bone Marrow Transplant for Sarcoma
This study is testing if a new drug called Nivolumab can help prevent or delay the return of high-risk sarcomas in children and adults after they receive a special type of bone marrow transplant.
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Collecting blood samples from cancer patients and healthy donors to study immune cells
This study is trying to see if it's possible to collect and grow certain immune cells from both cancer patients and healthy people to understand how well these cells can fight cancer.
Related topics
Quick answers
How many Solid Tumor, Adult clinical trials are recruiting right now?
76, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 22 countries. The most sites are in United States (45 trials), China (22 trials), Australia (10 trials), Spain (9 trials), France (9 trials). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 1: 29, Phase 1/2: 27, Phase 2: 5, Phase 2/3: 2. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.