Condition

Mesothelioma clinical trials and research

• 40Clinical trials
• 16NIH research projects
• 16Countries

Newest Mesothelioma clinical trials

All recruiting trials (40)

• SHY-ONC6: a new anti-cancer drug tested in adults with advanced solid tumors

  This early-phase study tests SHY-ONC6 to see if it is safe and can help people with advanced solid tumors after standard therapies have failed.

  Recruiting at 3 sites Phase 1 SHY Therapeutics · Scottsdale, Arizona and 2 other locations · NCT07705334

• Two-part Phase 1/2 test of ODM-212 combined with other cancer treatments

  This trial tests the oral drug ODM-212, given alone or with approved medicines, to see if it helps adults with advanced mesothelioma, pancreatic cancer, or non-small cell lung cancer.

  Recruiting at 23 sites Phase 1/2 Orion Corporation, Orion Pharma · Los Angeles, California and 22 other locations · NCT07563738

• IDE892 alone and with IDE397 for MTAP-deleted advanced solid tumors

  This trial tests IDE892 by itself and combined with IDE397 in adults whose advanced solid tumors have MTAP deletion and have progressed after standard treatments.

  Recruiting at 23 sites Phase 1 IDEAYA Biosciences · Goodyear, Arizona and 22 other locations · NCT07277413

• Partial pleurectomy to relieve symptoms from unresectable pleural mesothelioma.

  The team will try a limited partial pleurectomy and decortication to reduce chest symptoms and improve quality of life for people with epithelioid pleural mesothelioma that cannot be completely removed.

  Recruiting University of Chicago · Chicago, Illinois · NCT07126509

• Partial pleurectomy to relieve symptoms from unresectable pleural mesothelioma.

  The team will try a limited partial pleurectomy and decortication to reduce chest symptoms and improve quality of life for people with epithelioid pleural mesothelioma that cannot be completely removed.

  Recruiting University of Chicago · Chicago, Illinois · NCT07126509

• Neoadjuvant chemo‑immunotherapy to make inoperable epithelioid pleural mesothelioma operable (NECIM)

  This trial tests whether two cycles of cisplatin or carboplatin with pemetrexed plus the immunotherapies nivolumab and ipilimumab can enable surgery for adults with previously inoperable epithelioid pleural mesothelioma.

  Recruiting Phase 1/2 University Hospital, Antwerp · Edegem, Antwerp · NCT07121374

• International registry for very rare childhood tumors

  This project will collect detailed medical information to see how clinical and biological features affect outcomes in children and adolescents with very rare tumors.

  Recruiting Azienda Ospedaliera di Padova · Padova, Italy · NCT07072143

• Long-term clinical and tissue data collection for people with thoracic cancers

  This project will collect medical records, imaging, quality-of-life information, and tissue/blood samples over time from adults with thoracic cancers to try to find factors that predict outcomes.

  Recruiting at 11 sites Dutch Society of Physicians for Pulmonology and Tuberculosis · Ede, Gelderland and 22 other locations · NCT06996249

• Anti-mesothelin TNhYP218 CAR T cell therapy for mesothelin-expressing solid tumors

  This treatment will test whether a person's own engineered CAR T cells that target mesothelin can help adults with mesothelin-expressing solid tumors, including mesothelioma, that have returned or spread after standard therapy.

  Recruiting Phase 1 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06885697

• Targeted therapy using Lead-212 for solid tumors

  This study is testing a new targeted radiation treatment for patients with solid tumors that have a specific protein to see if it can effectively treat their cancer while protecting healthy tissue.

  Recruiting at 16 sites Phase 1/2 Perspective Therapeutics · Los Angeles, California and 15 other locations · NCT06710756

• Using portable dynamic chest X-ray in the ICU

  This study is testing a new portable chest X-ray system in the ICU to see if it can give better pictures of lung movement and function compared to regular X-rays and CT scans for critically ill patients.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06538376

• Exploring new approaches to treat mesothelioma

  This study is trying to see if targeting certain proteins can help improve treatment and immune response for people with mesothelioma.

  Recruiting at 2 sites IRCCS Ospedale San Raffaele · Naples, Campania and 1 other locations · NCT06536179

• Using a new imaging agent to detect various cancers

  This study is testing a new imaging agent to see if it can better detect certain cancers in adults compared to standard imaging methods.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06503146

• Treatment with Sacituzumab Govitecan for Mesothelioma

  This study tests if a new treatment called sacituzumab govitecan can help people with mesothelioma who have already tried other therapies feel better and manage their disease.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT06477419

• Treatment with Sacituzumab Govitecan for Mesothelioma

  This study tests if a new treatment called sacituzumab govitecan can help people with mesothelioma who have already tried other therapies feel better and manage their disease.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT06477419

• Evaluating BGC515 Capsules for Advanced Solid Tumors

  This study is testing a new capsule called BGC515 to see if it can help people with advanced solid tumors that haven't improved with standard treatments.

  Recruiting Phase 1 BridGene Biosciences Inc. · Houston, Texas · NCT06452160

• Treatment of advanced solid tumors with VET3-TGI immunotherapy

  This study is testing a new cancer treatment called VET3-TGI to see if it can safely target and kill cancer cells in patients with advanced solid tumors, either by injecting it directly into the tumors or giving it through an IV.

  Recruiting at 7 sites Phase 1 KaliVir Immunotherapeutics · Los Angeles, California and 6 other locations · NCT06444815

• Testing MDX2001 for advanced solid tumors

  This study is testing a new drug called MDX2001 to see if it can safely help people with advanced solid tumors like breast or colon cancer.

  Recruiting at 6 sites Phase 1/2 ModeX Therapeutics, An OPKO Health Company · Denver, Colorado and 5 other locations · NCT06239194

• CAR-γδT cell therapy targeting GPC3 and Mesothelin for cancer treatment

  This study is testing a new cancer treatment that uses modified immune cells to target specific proteins in patients with advanced solid tumors.

  Recruiting Phase 1 Second Affiliated Hospital of Guangzhou Medical University · Guangzhou, Guangdong · NCT06196294

• Additional chemotherapy after surgery for malignant peritoneal mesothelioma

  This study is testing whether giving chemotherapy directly into the abdomen or through an IV after surgery helps people with malignant peritoneal mesothelioma do better.

  Recruiting at 9 sites Phase 2 Memorial Sloan Kettering Cancer Center · Chicago, Illinois and 12 other locations · NCT06057935

• Evaluating a new CAR T-cell therapy for solid tumors expressing MSLN

  This study is testing a new CAR T-cell therapy to see if it can safely treat adults with solid tumors like colorectal and lung cancer that express a specific protein.

  Recruiting at 12 sites Phase 1/2 A2 Biotherapeutics Inc. · Gilbert, Arizona and 11 other locations · NCT06051695

• Oral treatment for early-stage mesothelioma in patients with BAP1 mutations

  This study is testing if a new oral treatment can help people with early-stage mesothelioma who have BAP1 mutations feel better and live longer.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT05960773

• Combination of immunotherapy and chemotherapy for mesothelioma treatment

  This study is testing whether combining two immunotherapy drugs with chemotherapy can help people with a type of lung cancer called mesothelioma live longer without their cancer coming back.

  Recruiting Phase 1/2 Baylor College of Medicine · Durham, North Carolina and 1 other locations · NCT05932199

• Using magnesium to prevent kidney injury in mesothelioma patients during surgery

  This study is testing if giving high doses of magnesium during surgery can help prevent kidney injury in patients with mesothelioma who are receiving chemotherapy.

  Recruiting Phase 2 Brigham and Women's Hospital · Boston, Massachusetts · NCT05730816

• Testing a new antibody for advanced solid tumors

  This study is testing a new antibody treatment for people with advanced solid tumors that haven't responded to other therapies to see how safe it is and how well it works.

  Recruiting Phase 1 A&G Pharmaceutical Inc. · Baltimore, Maryland · NCT05627960

• Testing Rinatabart Sesutecan for advanced solid tumors

  This study is testing a new drug called Rinatabart Sesutecan to see if it can safely help people with advanced solid tumors, like certain types of ovarian and endometrial cancers.

  Recruiting at 67 sites Phase 1/2 Genmab · Phoenix, Arizona and 66 other locations · NCT05579366

• Testing MRTX1719 for solid tumors with MTAP deletion

  This study is testing a new drug called MRTX1719 to see if it can help people with advanced solid tumors that have a specific gene deletion.

  Recruiting at 22 sites Phase 1 Bristol-Myers Squibb · Phoenix, Arizona and 24 other locations · NCT05245500

• Analyzing solid tumors for HLA loss and collecting T cells for CAR T-cell therapy

  This study is testing how often solid tumors lose a key protein that helps the immune system recognize them, while also collecting T cells from patients with high-risk cancers to prepare for future CAR T-cell therapy.

  Recruiting at 13 sites A2 Biotherapeutics Inc. · Gilbert, Arizona and 15 other locations · NCT04981119

• Analyzing solid tumors for HLA loss and collecting T cells for CAR T-cell therapy

  This study is testing how often solid tumors lose a key protein that helps the immune system recognize them, while also collecting T cells from patients with high-risk cancers to prepare for future CAR T-cell therapy.

  Recruiting at 13 sites A2 Biotherapeutics Inc. · Gilbert, Arizona and 15 other locations · NCT04981119

• Understanding BAP1 Hereditary Cancer Risks

  This study is trying to find out how common certain cancers are in people with BAP1 gene mutations to help improve screening and treatment for them and their families.

  Recruiting Ohio State University · Columbus, Ohio · NCT04792463

• Evaluating VT3989 for patients with metastatic solid tumors

  This study is testing a new drug called VT3989 to see if it can help people with hard-to-treat metastatic solid tumors, including mesothelioma, feel better and fight their cancer.

  Recruiting at 12 sites Phase 1/2 Vivace Therapeutics, Inc · San Francisco, California and 11 other locations · NCT04665206

• Using Olaparib for Patients with Malignant Mesothelioma and Genetic Mutations

  This study is testing if the drug olaparib can help people with malignant mesothelioma who have certain genetic mutations by seeing if it can shrink their tumors.

  Recruiting Phase 2 University of Chicago · Chicago, Illinois · NCT04515836

• Monitoring for early detection of mesothelioma in patients with BAP1 mutations

  This study is testing if advanced imaging and blood tests can help find mesothelioma early in people with BAP1 mutations who are at higher risk for this cancer.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT04431024

• Using MRI to guide radiation therapy for various cancers

  This study is testing if using MRI scans to adjust radiation therapy can help people with different types of cancer, like pancreatic and lung cancer, feel better and control their tumors more effectively.

  Recruiting at 2 sites Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT04115254

• Long-term follow-up of mesothelioma patients with specific gene mutations

  This study is looking to see how mesothelioma and certain gene mutations affect patients and their families over time, and it includes people aged 2 and older who have these mutations.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT03830229

• Evaluating new methods for staging and prognosis in malignant pleural mesothelioma

  This study is testing a new way to better understand the stage and outlook of malignant pleural mesothelioma by looking at tissue samples from patients to help doctors make more informed treatment decisions.

  Recruiting Dana-Farber Cancer Institute · Boston, Massachusetts · NCT03683680

• Treatment of solid tumors or lymphoma with VMD-928

  This study is testing a new oral medication called VMD-928 to see if it can help adults with advanced solid tumors or lymphoma that haven't improved with standard treatments.

  Recruiting at 13 sites Phase 1/2 VM Oncology, LLC · Santa Rosa, California and 12 other locations · NCT03556228

• Identifying biomarkers and treatment strategies for peritoneal surface malignancies

  This study is trying to find specific markers in patients with peritoneal surface cancers to help choose the best treatment options and improve their chances of recovery.

  Recruiting Oslo University Hospital · Oslo · NCT02073500

• A resource for collecting cancer data and biospecimens

  This study is creating a resource to collect health information and samples from cancer patients and healthy individuals to help improve cancer prevention and treatment strategies.

  Recruiting at 42 sites University of Nebraska · Greenwood Village, Colorado and 41 other locations · NCT02012699

• Collecting samples and studying the natural history of malignant mesothelioma

  This study is collecting tissue samples from people with malignant mesothelioma and certain other cancers to learn more about the disease and help improve future treatments.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT01950572

NIH-funded research (16)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• National Mesothelioma Biobank expands patient biospecimen and data sharing for research

  A national biobank collects blood, tissue, and clinical data from mesothelioma patients to help researchers develop better diagnostics and treatments.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11619061

• Intraperitoneal CAR T cells for peritoneal mesothelioma

  A new approach uses CAR T cells delivered directly into the abdominal cavity to target mesothelioma, aiming to help people whose disease is confined to the abdomen.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11443990

• Liquid multiomics to tailor systemic treatment for malignant pleural mesothelioma

  Researchers are testing liquid biomarkers to help choose personalized treatments for people with malignant pleural mesothelioma.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11414823

• New ways to make mesothelioma treatment work better

  This project looks at whether common antidepressant drugs plus a drug that blocks Mcl-1 can help chemotherapy work better for people with malignant mesothelioma.

  NIH research University of Hawaii at Manoa · Honolulu, United States · NIH-11325290

• Targeting mitochondria to help immunotherapy work better for pleural mesothelioma

  The team will try medicines that change cancer cell mitochondria to help immunotherapy work better for people with malignant pleural mesothelioma.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11289458

• Tumor-targeted imaging and alpha-particle therapy for mesothelioma

  This project develops an antibody-based imaging approach and a targeted alpha-particle therapy to find and kill mesothelioma tumors, including hard-to-treat sarcomatoid cases.

  NIH research University of Virginia · Charlottesville, United States · NIH-11252001

• Photofrin and heme oxygenase–boosting drugs for pleural mesothelioma

  This work looks at whether Photofrin and drugs that boost heme oxygenase can slow tumor growth in people with malignant pleural mesothelioma.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11251934

• National Mesothelioma Virtual Bank — patient biosamples and data network

  Collects and shares tissue, blood, and medical information from people with mesothelioma to help researchers develop better tests and treatments.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11121710

• Understanding how certain proteins affect treatment response in a type of lung cancer

  This study is looking at certain proteins in tumors from patients with malignant pleural mesothelioma to see if they can help doctors figure out who will benefit from new immune treatments, making it easier to choose the right options and improve survival rates.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11094910

• New methods to enhance treatment for mesothelioma

  This study is looking at how certain antidepressant medications might help make chemotherapy work better for people with malignant mesothelioma, a type of cancer caused by asbestos exposure, by blocking the ways cancer cells protect themselves.

  NIH research University of Hawaii at Manoa · Honolulu, United States · NIH-11074658

• Targeting a specific tumor marker for imaging and treatment of mesothelioma

  This study is testing a new way to use targeted radiation therapy to treat the tough-to-treat sarcomatoid subtype of malignant mesothelioma, aiming to provide patients with a more effective and precise treatment that focuses on the tumor while protecting healthy tissue.

  NIH research University of Virginia · Charlottesville, United States · NIH-11057986

• Using targeted therapies to improve treatment outcomes for malignant pleural mesothelioma

  This study is looking at new ways to treat malignant pleural mesothelioma, a type of cancer caused by asbestos, by using special medicines that help your immune system fight the cancer better, and it’s for patients who don’t have many treatment choices right now.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11053605

• Using Photofrin and heme oxygenase inducers to treat mesothelioma

  This study is looking at how a drug called Photofrin, which is usually used with light therapy, might help fight malignant pleural mesothelioma on its own, along with another treatment that boosts the immune system, to see if it can improve survival for patients dealing with this tough cancer.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11034841

• A virtual bank for collecting and sharing mesothelioma patient data and samples.

  This study is gathering blood and tissue samples from people with mesothelioma to help researchers learn more about the disease and find better treatments, and they're looking to include more patients from different backgrounds to make the research even more helpful.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10849611

• Using sulforaphane from broccoli to prevent malignant mesothelioma

  This study is looking at whether a natural compound from broccoli called sulforaphane can help prevent malignant mesothelioma, a serious cancer often caused by asbestos, especially in people who are at higher risk for cancer.

  NIH research Research Inst of Fox Chase Can Ctr · Philadelphia, United States · NIH-10836806

• Investigating how a gene linked to Parkinson's disease affects a type of cancer caused by asbestos exposure.

  This study is looking at how a gene related to Parkinson's disease might affect the growth of malignant mesothelioma, a serious cancer linked to asbestos exposure, to find new ways to treat it.

  NIH research Research Inst of Fox Chase Can Ctr · Philadelphia, United States · NIH-10832656

Related topics

Quick answers

How many Mesothelioma clinical trials are recruiting right now?

40, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 16 countries. The most sites are in United States (34 trials), China (2 trials), Italy (2 trials), Australia (1 trial), Japan (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 9, Phase 1: 8, Phase 2: 7. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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