Testing CX-2051 for advanced solid tumors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This first-in-human study aims to evaluate the safety, tolerability, and preliminary antitumor activity of CX-2051 in adults with advanced solid tumors. The study consists of two parts: the first part focuses on dose escalation to determine the maximum tolerated dose (MTD), while the second part involves dose expansion to further assess safety and tolerability, along with initial evaluations of antitumor activity in specific cohorts. Participants will receive CX-2051 and will be monitored for responses and side effects.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Metastatic or locally advanced unresectable solid tumor that has progressed after standard therapy
* Eastern Cooperative Oncology Group (ECOG) performance status of 0-1
* Measurable disease per RECIST v1.1
* Consent to fresh biopsy or if medically contraindicated, recent (within 6 months) archival tumor tissue
* Additional inclusion criteria may apply

Exclusion Criteria:

* Recent history (within last 2 years) of localized cancers that are not related to the current cancer being treated
* Known active central nervous system (CNS) involvement by malignancy
* Systemic anticancer treatment, radiotherapy, or investigational agent(s) within 14 days prior to C1D1
* Previous treatment with antibody-drug conjugates (ADCs) with Topo-I inhibitor payload
* Major surgery (requiring general anesthesia) within 4 weeks prior to C1D1
* Elevated baseline laboratory values
* Serious concurrent illness
* Pregnant or breast feeding
* Additional exclusion criteria may apply

Where it's running

• Sarah Cannon Research Institute at HealthONE
  Denver, Colorado, United States Recruiting
• Dana-Farber Cancer Institute
  Boston, Massachusetts, United States Recruiting
• Montefiore Medical Center
  The Bronx, New York, United States Recruiting
• Carolina BioOncology Institute, PLLC
  Huntersville, North Carolina, United States Recruiting
• Sarah Cannon Research Institute, LLC
  Nashville, Tennessee, United States Recruiting
• START - Dallas/Fort Worth
  Fort Worth, Texas, United States Recruiting

Study contacts

• Study coordinator: Karen Deane
• Email: clinicaltrials@cytomx.com
• Phone: 650-515-3185

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.