Injection of drug-eluting microspheres into tumors
Official title: Intra-tumor Injection of Drug-eluting Microspheres Loading With Chemodrug Plus Checkpoint Inhibitors and/or IL2 for Treatment of Advanced Solid Tumors
Run by Second Affiliated Hospital of Guangzhou Medical University · NCT04770207 · Data updated 2026-11-12
This study tests if injecting tiny drug-filled beads directly into advanced tumors can safely help people with cancer feel better and improve their treatment outcomes.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 99 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Second Affiliated Hospital of Guangzhou Medical University Academic / other |
| Drugs / interventions | doxorubicin |
| Locations | 1 site (Guangzhou, Guangdong) |
| Status | Recruiting |
| Started | November 1, 2020 |
| Main results expected | November 1, 2029 |
| Study ends | November 1, 2035 |
| Registry record updated | August 21, 2024 |
| Trial ID | NCT04770207 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 to 99 with advanced solid malignant tumors and a life expectancy of more than three months.
✕Probably not a fit
Patients with benign tumors, a life expectancy of less than three months, or serious medical comorbidities may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the safety and clinical effects of injecting drug-eluting microspheres loaded with various drugs directly into advanced solid tumors, including hepatocellular carcinoma. The microspheres will contain a combination of immunotherapeutic agents and chemotherapeutics, such as IL2 and PD1/PDL1/CTLA4 antibodies, and will be administered under CT guidance. The efficacy and side effects of this treatment will be evaluated using established clinical standards.
Why it matters
Potential benefit: If successful, this approach could provide a novel and effective treatment option for patients with advanced solid tumors.
How similar studies have gone: While this approach is innovative, similar studies using drug-eluting microspheres have shown promise in treating various cancers, indicating potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Solid advanced malignant tumors * Age between18 and 99 years * Life expectancy is greater than three months Exclusion Criteria: * Benign tumor * Life expectancy is less than three months * Serious medical comorbidity * Others
Where it's running
-
The Second Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, China Recruiting
Study contacts
- Principal investigator: Zhenfeng Zhang, MD, PhD — Second Affiliated Hospital of Guangzhou Medical University
- Study coordinator: Bingjia He, MD
- Email: 464677938@qq.com
- Phone: +862039195965
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.