Clinical trial Recruiting at 1 site Phase 2 Interventional Ages 18 to 99

Injection of drug-eluting microspheres into tumors

Official title: Intra-tumor Injection of Drug-eluting Microspheres Loading With Chemodrug Plus Checkpoint Inhibitors and/or IL2 for Treatment of Advanced Solid Tumors

Run by Second Affiliated Hospital of Guangzhou Medical University · NCT04770207 · Data updated 2026-11-12

This study tests if injecting tiny drug-filled beads directly into advanced tumors can safely help people with cancer feel better and improve their treatment outcomes.

More Hepatocellular Carcinoma trials

Quick facts

PhasePhase 2
Study typeInterventional
Ages18 Years to 99 Years
SexAll
Enrollment100 (estimated)
SponsorSecond Affiliated Hospital of Guangzhou Medical University
Academic / other
Drugs / interventionsdoxorubicin
Locations1 site (Guangzhou, Guangdong)
StatusRecruiting
StartedNovember 1, 2020
Main results expectedNovember 1, 2029
Study endsNovember 1, 2035
Registry record updatedAugust 21, 2024
Trial IDNCT04770207 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults aged 18 to 99 with advanced solid malignant tumors and a life expectancy of more than three months.

Probably not a fit

Patients with benign tumors, a life expectancy of less than three months, or serious medical comorbidities may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the safety and clinical effects of injecting drug-eluting microspheres loaded with various drugs directly into advanced solid tumors, including hepatocellular carcinoma. The microspheres will contain a combination of immunotherapeutic agents and chemotherapeutics, such as IL2 and PD1/PDL1/CTLA4 antibodies, and will be administered under CT guidance. The efficacy and side effects of this treatment will be evaluated using established clinical standards.

Why it matters

Potential benefit: If successful, this approach could provide a novel and effective treatment option for patients with advanced solid tumors.

How similar studies have gone: While this approach is innovative, similar studies using drug-eluting microspheres have shown promise in treating various cancers, indicating potential for success.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Solid advanced malignant tumors
* Age between18 and 99 years
* Life expectancy is greater than three months

Exclusion Criteria:

* Benign tumor
* Life expectancy is less than three months
* Serious medical comorbidity
* Others

Where it's running

  • The Second Affiliated Hospital of Guangzhou Medical University
    Guangzhou, Guangdong, China
    Recruiting

Study contacts

  • Principal investigator: Zhenfeng Zhang, MD, PhD — Second Affiliated Hospital of Guangzhou Medical University
  • Study coordinator: Bingjia He, MD
  • Email: 464677938@qq.com
  • Phone: +862039195965

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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    This study is testing a new combination of three drugs to see if it can help people with advanced solid tumors, like liver cancer, feel better and improve their condition.

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  • InstaSure Non-Invasive Finger-Press Test for HCC

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  • Zinc add-on with targeted therapy plus immunotherapy for advanced liver cancer

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    Recruiting Phase 2 Anhui Provincial Hospital · Hefei, Anhui · NCT07793695

  • 68Ga-SorB PET/CT imaging for solid tumors

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  • HMPL-A830 in solid tumors for adults with unresectable or metastatic cancer

    This first-in-human study tests HMPL-A830 in adults with unresectable or metastatic solid tumors to see how safe it is and how it behaves at varying doses.

    Recruiting at 4 sites Phase 1/2 Hutchmed · Orange, California and 13 other locations · NCT07718581

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.