Condition

CRC clinical trials and research

• 14Clinical trials
• 1New in 30 days
• 10Countries

Newest CRC clinical trials

All recruiting trials (14)

• Targeted alpha therapy for B7-H3 expressing solid tumors using AKY-2519

  This phase 1b trial tests a radiolabeled drug (AKY-2519) to see if it's safe and tolerable in adults with B7-H3 positive advanced solid tumors, including NSCLC and SCLC, with imaging to help guide use.

  Recruiting at 2 sites Phase 1 Aktis Oncology, Inc. · Miami, Florida and 1 other locations · NCT07887971

• Urine test to help spot colorectal cancer and polyps

  This study tests a urine-based 3-metabolite biosensor to see if it can detect colorectal cancer and precancerous polyps in adults in Ghana, Tanzania, and South Africa.

  Recruiting Memorial Sloan Kettering Cancer Center · New York, New York and 3 other locations · NCT07649057

• Combining RAS(ON) inhibitors with ivonescimab for adults with RAS‑mutant advanced solid tumors

  This trial will test whether combining RAS(ON) inhibitors with ivonescimab is safe and can shrink or control tumors in adults with advanced or metastatic solid tumors that have RAS mutations.

  Recruiting at 19 sites Phase 1/2 Revolution Medicines, Inc. · Scottsdale, Arizona and 18 other locations · NCT07397338

• RMC-5127 for advanced cancers with KRAS G12V mutation

  This trial will test whether the experimental drug RMC-5127, alone or with daraxonrasib or cetuximab, helps adults with advanced KRAS G12V-mutant solid tumors.

  Recruiting at 9 sites Phase 1 Revolution Medicines, Inc. · New Haven, Connecticut and 8 other locations · NCT07349537

• CBI-1214 T-cell engager for advanced MSS/MSI-L colorectal cancer

  This trial will test whether the experimental T-cell engager CBI-1214 is safe, reaches appropriate blood levels, and can shrink tumors in people with advanced or metastatic MSS/MSI-L colorectal cancer who have had prior treatment.

  Recruiting at 10 sites Phase 1 Cartography Biosciences · Phoenix, Arizona and 9 other locations · NCT07321106

• HS-20110 with bevacizumab and chemotherapy for advanced colorectal cancer

  This trial will test whether adding HS-20110 to bevacizumab plus standard chemotherapy helps adults with advanced colorectal cancer.

  Recruiting Phase 1/2 Hansoh BioMedical R&D Company · Guangzhou · NCT07283367

• HCB101 combined with cetuximab or bevacizumab plus FOLFOX/FOLFIRI for advanced metastatic colorectal cancer

  This trial tries weekly HCB101 infusions together with cetuximab or bevacizumab and FOLFOX or FOLFIRI chemotherapy in adults with advanced or metastatic RAS/BRAF wild-type colorectal cancer who have progressed after prior chemotherapy.

  Recruiting Phase 1/2 Chang Gung Memorial Hospital · Taoyuan · NCT07204574

• Adding antibiotics to chemotherapy for colorectal cancer treatment

  This study is testing if adding antibiotics and aspirin to standard chemotherapy can help people with stage IV colorectal cancer respond better to their first treatment.

  Recruiting at 2 sites Phase 2 Virginia Commonwealth University · Richmond, Virginia and 1 other locations · NCT06728072

• Evaluating a new CAR T-cell therapy for solid tumors expressing EGFR

  This study is testing a new CAR T-cell therapy to see if it can safely help adults with certain solid tumors, like colorectal and lung cancer, that have specific markers.

  Recruiting at 10 sites Phase 1/2 A2 Biotherapeutics Inc. · Gilbert, Arizona and 9 other locations · NCT06682793

• Testing TUB-030 for advanced solid tumors

  This study is testing a new drug called TUB-030 to see if it can safely help adults with advanced solid tumors, especially those with head and neck cancer or non-small cell lung cancer.

  Recruiting at 19 sites Phase 1/2 Gilead Sciences · New Haven, Connecticut and 19 other locations · NCT06657222

• Evaluating RAS(ON) Inhibitors for Gastrointestinal Solid Tumors

  This study is testing new RAS(ON) inhibitors combined with standard treatments to see if they can help people with certain types of gastrointestinal cancers that have RAS mutations.

  Recruiting at 32 sites Phase 1/2 Revolution Medicines, Inc. · Chandler, Arizona and 31 other locations · NCT06445062

• Treatment with SPX-303 for patients with solid tumors

  This study is testing a new treatment called SPX-303 for patients with solid tumors that haven't improved with previous therapies to see if it can help them feel better.

  Recruiting at 4 sites Phase 1 SparX Biotech(Jiangsu) Co., Ltd. · Phoenix, Arizona and 3 other locations · NCT06259552

• Evaluating a new CAR T-cell therapy for solid tumors expressing MSLN

  This study is testing a new CAR T-cell therapy to see if it can safely treat adults with solid tumors like colorectal and lung cancer that express a specific protein.

  Recruiting at 12 sites Phase 1/2 A2 Biotherapeutics Inc. · Gilbert, Arizona and 11 other locations · NCT06051695

• Analyzing solid tumors for HLA loss and collecting T cells for CAR T-cell therapy

  This study is testing how often solid tumors lose a key protein that helps the immune system recognize them, while also collecting T cells from patients with high-risk cancers to prepare for future CAR T-cell therapy.

  Recruiting at 13 sites A2 Biotherapeutics Inc. · Gilbert, Arizona and 15 other locations · NCT04981119

Related topics

Quick answers

How many CRC clinical trials are recruiting right now?

14, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in United States (12 trials), China (1 trial), Taiwan (1 trial), Canada (1 trial), France (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 7, Phase 1: 4, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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