Clinical trial Recruiting at 1 site Phase 2 Interventional Ages 18 to 85

Combination treatment for advanced solid tumors using Trametinib, Everolimus, and Lenvatinib

Official title: Trametinib Combined With Everolimus and Lenvatinib in the Treatment of Recurrent/Refractory Advanced Solid Tumors: a Phase II Clinical Trial

Run by Second Affiliated Hospital of Guangzhou Medical University · NCT04803318 · Data updated 2026-11-12

This study is testing a new combination of three drugs to see if it can help people with advanced solid tumors, like liver cancer, feel better and improve their condition.

Quick facts

PhasePhase 2
Study typeInterventional
Ages18 Years to 85 Years
SexAll
Enrollment100 (estimated)
SponsorSecond Affiliated Hospital of Guangzhou Medical University
Academic / other
Drugs / interventionsTrametinib, Lenvatinib
Locations1 site (Guangzhou, Guangdong)
StatusRecruiting
StartedJanuary 1, 2021
Main results expectedJanuary 1, 2029
Study endsJanuary 1, 2037
Registry record updatedJune 25, 2024
Trial IDNCT04803318 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults aged 18 to 85 with recurrent or refractory advanced solid tumors and an expected life expectancy of more than three months.

Probably not a fit

Patients with benign tumors, a life expectancy of less than three months, or serious medical comorbidities may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of a combination therapy using Trametinib, Everolimus, and Lenvatinib for patients with recurrent or refractory advanced solid tumors, including hepatocellular carcinoma. The study aims to measure tumor diameter and evaluate the efficacy of the treatment regimen after administration. Participants will be monitored for their response to the therapy, providing valuable data on its potential benefits and effectiveness.

Why it matters

Potential benefit: If successful, this treatment could offer a new therapeutic option for patients with advanced solid tumors that have not responded to previous treatments.

How similar studies have gone: While this approach combines established therapies, the specific combination of Trametinib, Everolimus, and Lenvatinib for this indication is novel and has not been extensively tested in prior studies.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Recurrent/Refractory advanced solid tumors
* Age between 18 and 85 years
* Expected life expectancy is greater than three months

Exclusion Criteria:

* Benign tumor
* Life expectancy is less than three months
* Serious medical commodities
* others

Where it's running

  • The Second Affiliated Hospital of Guangzhou Medical University
    Guangzhou, Guangdong, China
    Recruiting

Study contacts

  • Principal investigator: Zhenfeng Zhang, MD, PhD — Second Affiliated Hospital of Guangzhou Medical University
  • Study coordinator: Zhenfeng Zhang, MD, PhD
  • Email: zhangzhf@gzhmu.edu.cn
  • Phone: +862039195966

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.