Testing HQP1351 for GIST and other solid tumors

A Phase I Study to Assess the Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Properties of Oral HQP1351 in Patients With GIST or Other Solid Tumors.

This study is testing a new drug called HQP1351 to see if it can help people with gastrointestinal stromal tumors and other solid tumors feel better and how much of the drug is safe to use.

Quick facts

• Phase: Phase 1
• Study type: Interventional
• Enrollment: 100 (estimated)
• Ages: 12 Years and up
• Sex: All
• Sponsor: Ascentage Pharma Group Inc. (Industry-sponsored)
• Drugs / interventions: imatinib, chemotherapy, immunotherapy
• Locations: 6 sites (Guangzhou, Guangdong and 5 other locations)
• Trial ID: NCT03594422 on ClinicalTrials.gov

What this trial studies

This is a multi-center, open-label Phase 1 study aimed at determining the recommended Phase 2 dose (RP2D) of HQP1351 in patients with gastrointestinal stromal tumors (GIST) or other solid tumors. The study will evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary efficacy of HQP1351. Participants will be closely monitored for their response to the treatment and any adverse effects.

Who should consider this trial

Good fit: Ideal candidates include adults aged 12 and older with advanced or metastatic GIST or other solid tumors who have shown resistance to imatinib or other targeted therapies.

Not a fit: Patients with early-stage tumors or those who have not previously undergone treatment with imatinib may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could provide a new therapeutic option for patients with GIST and other solid tumors that are resistant to current therapies.

How similar studies have performed: Other studies have shown promise with similar targeted therapies in treating GIST, indicating potential for success with this approach.

Eligibility criteria

Inclusion Criteria:

1. Male or not pregnant or lactating women, age≥12years.
2. Advanced and/or metastatic GIST or other solid tumors, confirmed by histology and/or cytology. GIST patients must be primary resistant to imatinib (tumor progresses within 6 months first-line imatinib treatment, or succinate dehydrogenase B (SDHB) deficient confirmed by immunohistochemistry, or NF1 mutation), OR imatinib or imatinib and at least one other TKI treatment failure (after imatinib or other TKI treatment for more than 6 months, tumor progress again after achieving tumor remission or stability).
3. ECOG≤ 2.
4. Estimated survival at least 3 months.
5. Adequate hematologic and bone marrow functions.
6. Adequate renal and liver function.
7. Heart function index:

   * Troponin(I/T) ≤ Upper Limit of Normal;
   * Ejection fraction \>40%;
   * QTc interval ≤ 450 ms in male or ≤ 470 ms in female.
8. Negative serum pregnancy test (for women of childbearing potential) documented within the 24-hour prior to the first dose of investigational product.
9. Willing to use contraception by a method that is deemed effective by the investigator by Subject and their partners throughout the treatment period and for at least 30 days following the last dose of study drug.
10. Ability to understand and willingness to sign a written informed consent form (the consent form must be signed by the subject prior to any study-specific procedures).
11. Willing and ability to comply with study procedures and follow-up examination.

Exclusion Criteria:

1. Received any anti-cancer chemotherapy, biological agent treatment (e.g. Monoclonal antibody), immunotherapy (e.g. IFN) or radiotherapy with 28 days or 5 times half- time before first dose of HQP1351.
2. Received any TKIs within 14 days before first dose of HQP1351.
3. Attended any clinical trials on other drugs within 14 days before first dose of HQP1351.
4. Have not recovered (\> Grade 1 by CTCAE, v. 4.0) from AEs (except alopecia) due to agents previously administered.
5. Malabsorption syndrome or other diseases that affect the absorption of oral drugs.
6. Cardiovascular diseases of clinical significance, uncontrollable or active, including but not limited to: history of myocardial infarction; unstable history of angina pectoris; a history of congestive heart failure or lower left ventricular ejection fraction (LVEF) than normal limit within 6 months; the history of atrial arrhythmias was judged by the researchers to have important clinical significance; history of ventricular arrhythmias, etc.
7. Hypertension was still poorly controlled after medication treatment (SBP \> 140 mmHg and/or DBP \> 90 mmHg).
8. Concurrent use any medication led to prolong QT interval.
9. Pulmonary mean arterial pressure\>35 mmHg by ECHO.
10. Significant severe cardiovascular conditions during previous TKI treatment.
11. Uncontrollable hypertriglyceridemia.
12. Performed major surgery (except for intravenous catheterization or bone marrow biopsy) within 14 days of first dose of HQP1351.
13. Arterial thrombosis or embolism events such as cerebrovascular accident (including transient ischemic attack, TIA), or venous thrombosis events or pulmonary embolism within 6 months before the first dose of HQP1351 or deep vein thrombosis within 3 months before the first dose of HQP1351.
14. Brain metastasis.
15. Had other primary malignant tumors in the last three years (exception of the tumors being cured for 5 years or more, or complete removal of non-melanoma skin cancer or successful treatment of carcinoma in situ, or the controlled prostate cancer).
16. Had active, symptomatic infections (including known infections of HIV, viral hepatitis (A, B, or C)). If there is no history of infection, screening is not required.
17. Subjects who are known to be allergic to pharmaceutical ingredients or their analogs.
18. Pregnancy or lactation, or expect to be pregnant during the study period.
19. According to the judgment of the investigator or sponsor, any symptoms or disease of the subject may jeopardize the safety or safety assessment of the subject.
20. Any other condition or circumstance of that would, in the opinion of the investigator, make the patient unsuitable for participation in the study.

Where this trial is running

Guangzhou, Guangdong and 5 other locations

• Sun-Yat Sen University Cancer Center — Guangzhou, Guangdong, China (Recruiting)
• Guangdong general hospital — Guangzhou, Guangdong, China (Recruiting)
• Henan cancer hospital — Zhengzhou, Henan, China (Recruiting)
• Union Hospital Tongji Medical College of Huazhong University of Science ang Technology — Wuhan, Hubei, China (Recruiting)
• Chinese PLA general hospital, Beijing, China — Beijing, China (Recruiting)
• Fudan University Shanghai Cancer Center — Shanghai, China (Recruiting)

Study contacts

• Principal investigator: Ruihua Xu, Professor — Sun Yat-Sen University Cancer Center
• Study coordinator: Yifan Zhai, M.D., Ph.D.

Conditions Gastrointestinal Stromal Tumor; Solid Tumor, Adult