Improving genetic testing for cancer patients through nurse-led support

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot study aims to enhance the uptake of genetic counseling and testing (GCT) among adult patients diagnosed with solid tumors by utilizing an oncology nurse-led intervention. The study addresses the significant barriers to GCT, particularly the low referral rates from oncologists, by providing enhanced education and support to patients. By identifying germline risks, the study seeks to improve patient outcomes through tailored cancer surveillance and treatment options. The intervention will be implemented at community cancer centers, focusing on patients eligible for GCT based on established guidelines.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults (≥ 18 years)
* Diagnosed with a solid tumor cancer type that has established guidelines suggesting the utility of genetic testing in treatment (breast, ovarian, prostate, pancreatic, colon, Lynch syndrome-related cancers (colorectal, endometrial, gastric, ovarian, pancreatic, urothelial, brain (usually glioblastoma), biliary tract, small intestine), Li-Fraumeni syndrome tumor spectrum (e.g., soft tissue sarcoma, osteosarcoma, central nervous system tumors, breast cancer, adrenocortical carcinoma), etc.)
* Eligible for GCT based on the current NCCN guidelines
* Starting new systemic therapy or switching systemic therapy
* Eligible for GCT as per the current NCCN guidelines
* No prior genetic testing (or tested before 2014)

Exclusion Criteria:

* Prior GCT with test results available (if tested 2014 onwards)
* Patients scheduled for treatment education with Advanced Practice Provider (typically reserved for more complex regimens)
* Patients with cognitive impairments or severe psychological disorders that would limit their ability to understand the genetic counseling/testing information or give informed consent.
* Any other condition that would, in the investigator's judgment, contraindicate the patient's participation in the clinical study due to safety concerns with clinical study procedures (e.g., patients requiring urgent therapy and/or inpatient chemotherapy initiation).
* Patients who are currently participating in other clinical trials that could confound the outcomes of genetic testing uptake.
* Prospective participants who, in the investigator's opinion, may not be able to comply with all study procedures (including compliance issues related to logistics).
* Hematologic malignancy

Where it's running

• Enloe Regional Cancer Center
  Chico, California, United States Recruiting
• University of California, Davis
  Sacramento, California, United States Active not recruiting

Study contacts

• Principal investigator: Ranjan Pathak, MD MHS — Enloe Health
• Study coordinator: Rachel A Kitchen, CCRP
• Email: rkitchen@ucdavis.edu
• Phone: 406-417-1576

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.