Condition

Scoliosis clinical trials and research

• 35Clinical trials
• 12NIH research projects
• 17Countries

Newest Scoliosis clinical trials

All recruiting trials (35)

• Sleep quality in adolescents with scoliosis

  This study tests whether adolescents with idiopathic scoliosis have different sleep quality than healthy peers aged 10–18.

  Recruiting Bezmialem Vakif University · Istanbul · NCT07767591

• Reiki vs sham after lumbar surgery to see if pain improves

  A randomized, double-blind test to see if Reiki, added to standard care, can lower pain after lumbar surgery compared with a sham treatment.

  Recruiting at 2 sites Clinique Bizet · Paris and 1 other locations · NCT07722117

• Blood Transfusion Factors and Cell Saver Use in Kids’ Spine Surgery

  This study looks at which factors put pediatric scoliosis patients at risk for needing donor blood during posterior spinal fusion and how using a Cell Saver during surgery might reduce that need.

  Recruiting Tunis University · Tunis · NCT07661589

• Understanding subtypes of chronic musculoskeletal pain in youth

  This observational study tests whether distinct brain and immune profiles can explain chronic musculoskeletal pain in teens and young adults to guide more precise treatments.

  Recruiting Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT07602595

• TXA in kids undergoing scoliosis surgery

  This trial tests whether tranexamic acid can reduce blood loss and the need for transfusions in children aged 10–18 having surgery for idiopathic scoliosis.

  Recruiting Poznan University of Medical Sciences · Poznan · NCT07581457

• Gender differences in pain during spinal roller exercises for adults with scoliosis.

  We will test whether adults with scoliosis feel different levels of pain during controlled spinal-pressure exercises using a physiotherapy roller, comparing men and women.

  Recruiting Uskudar University · Baku · NCT07447193

• eCential Robotics robot for more accurate pedicle screw placement in spine surgery

  This will test whether using the eCential Robotics robot improves the accuracy and safety of pedicle screw placement in patients aged 5 and older undergoing spine surgery, including for scoliosis.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT07421752

• Tegileridine for postoperative pain after adolescent scoliosis surgery

  This trial tests whether Tegileridine can provide pain relief after spine surgery in teens as well as morphine, using a patient-controlled pump and comparing safety profiles.

  Recruiting Phase 4 Peking Union Medical College Hospital · Zhengzhou, Henan and 5 other locations · NCT07229495

• High-resolution MRI of paravertebral (back) muscles in children with idiopathic or neuromuscular scoliosis

  We will use a short, extra high-resolution MRI to see if differences in the deep back muscles are linked to scoliosis in children aged 10–17 with idiopathic or neuromuscular forms.

  Recruiting Assistance Publique - Hôpitaux de Paris · Garches · NCT07135765

• Schroth method with and without core stabilization exercises for adolescents with idiopathic scoliosis

  This trial tests whether adding core stabilization exercises to the Schroth method helps teens (ages 10–18) with mild idiopathic scoliosis reduce spinal curve, build back endurance, increase chest mobility, and improve quality of life.

  Recruiting University of Lahore · Lahore, Punjab Province · NCT07059663

• Comparing lidocaine and regional anesthesia for pain management after scoliosis surgery

  This study is testing whether using lidocaine or a specific regional anesthesia technique can help reduce pain and the need for morphine in patients aged 12 and older after scoliosis surgery.

  Recruiting Assaf-Harofeh Medical Center · Be’er Ya‘aqov · NCT06451562

• Assessing balance in adults with spinal deformities

  This study is testing a new way to measure balance in adults with spinal deformities after surgery to see how it compares to healthy adults.

  Recruiting University of Kansas Medical Center · Kansas City, Kansas · NCT06258161

• Yoga for back pain in adolescents with scoliosis

  This study tests whether adding a structured yoga program to regular care can help teenagers with scoliosis and back pain feel better and improve their quality of life.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT06242821

• Yoga for back pain in adolescents with scoliosis

  This study tests whether adding a structured yoga program to regular care can help teenagers with scoliosis and back pain feel better and improve their quality of life.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT06242821

• Using melatonin to improve recovery in teens after surgery

  This study is testing if melatonin can help teenagers recover better and sleep well after having major surgery.

  Recruiting Stanford University · Palo Alto, California · NCT06093477

• Using melatonin to improve recovery in teens after surgery

  This study is testing if melatonin can help teenagers recover better and sleep well after having major surgery.

  Recruiting Stanford University · Palo Alto, California · NCT06093477

• Using melatonin to improve recovery in teens after surgery

  This study is testing if melatonin can help teenagers recover better and sleep well after having major surgery.

  Recruiting Stanford University · Palo Alto, California · NCT06093477

• Implantation of a device for delivering nusinersen in spinal muscular atrophy patients

  This study is testing a new device that delivers a treatment for spinal muscular atrophy directly into the spine to see if it is safe and works well for patients who have trouble with regular injections.

  Recruiting at 21 sites Alcyone Therapeutics, Inc · Phoenix, Arizona and 22 other locations · NCT05866419

• Evaluating body structure and capacity in adults with scoliosis

  This study looks at how scoliosis affects the physical abilities and body structure of adults to see how they compare to healthy individuals.

  Recruiting University of Alberta · Edmonton, Alberta · NCT05538871

• Research on quality of life improvements after scoliosis surgery in adolescents

  This study is trying to see how scoliosis surgery affects the quality of life for teenagers aged 12 to 20 and what factors might help them feel better afterward.

  Recruiting Elsan · Bruges · NCT05145725

• Assessing respiratory muscle function in children

  This study tests how strong the breathing muscles are in children with breathing problems to see if better treatments can help them breathe easier.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT05051254

• Analysis of a new spinal fixation system to prevent complications in adult spinal surgery

  This study tests if a new spinal fixation system can help adults undergoing spinal surgery avoid complications and improve their recovery compared to traditional methods.

  Recruiting at 7 sites International Spine Study Group Foundation · Phoenix, Arizona and 8 other locations · NCT04888104

• Evaluating minimally invasive surgery for complex adult spinal deformities

  This study is testing whether minimally invasive surgery can effectively treat complex spinal deformities in adults, like scoliosis and kyphosis, while also looking at costs and patient experiences.

  Recruiting at 11 sites International Spine Study Group Foundation · Phoenix, Arizona and 11 other locations · NCT04885244

• Registry for patients with personalized spine rods

  This study is testing whether personalized spine rods can help patients who have had spinal surgery feel better and have fewer problems compared to those with standard rods.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT04601363

• Evaluating outcomes of surgery for complex adult spinal deformities

  This study looks at how well surgery works for adults with complex spinal deformities like scoliosis and kyphosis to see if it can improve their health and reduce complications.

  Recruiting at 17 sites International Spine Study Group Foundation · La Jolla, California and 17 other locations · NCT04194138

• Erector spinae plane blockade for pain relief in children with scoliosis surgery

  This study is testing if a special pain relief method can help children feel less pain after spinal surgery for scoliosis while using fewer opioids.

  Recruiting Stanford University · Palo Alto, California · NCT04153994

• Erector spinae plane blockade for pain relief in children with scoliosis surgery

  This study is testing if a special pain relief method can help children feel less pain after spinal surgery for scoliosis while using fewer opioids.

  Recruiting Stanford University · Palo Alto, California · NCT04153994

• Evaluation of a rehabilitation program for spine pain

  This study is testing a new rehabilitation program for people with spine pain to see if it helps them feel better and recover using both in-clinic and online methods.

  Recruiting SpineZone Medical Fitness, Inc · San Diego, California · NCT04081896

• Assessing quality of life in adolescents with scoliosis who need bracing or surgery

  This study looks at how bracing or surgery for scoliosis affects the quality of life for teenagers who need these treatments.

  Recruiting Chinese University of Hong Kong · Shatin · NCT03915106

• Vitamin D's role in treating adolescent scoliosis

  This study is testing if giving vitamin D to teenagers with scoliosis can help improve their spinal shape and health over two years.

  Recruiting at 2 sites Phase 2 University of Ioannina · Asvestochóri and 1 other locations · NCT03582917

• Developing a shared decision-making tool for scoliosis treatment options

  This study is trying to create a helpful tool for patients with scoliosis to make better decisions about their treatment options by analyzing video visits with their doctors and families.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT03107533

• Survey to help families decide on scoliosis treatment

  This study is trying to understand what factors help families choose the best treatment for their child's scoliosis by collecting their thoughts on options like observation, bracing, or surgery.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT03017755

• Innovative textile braces for treating adolescent scoliosis

  This study is testing new textile braces for teenagers with scoliosis to see if they can help straighten their spines and improve their overall comfort and confidence.

  Recruiting at 2 sites The Hong Kong Polytechnic University · Hong Kong, Guangdong and 1 other locations · NCT02589106

• Evaluation of a new model to predict scoliosis progression in adolescents

  This study is testing a new way to predict which teenagers with scoliosis are likely to have their condition get worse, so doctors can provide better treatment options.

  Recruiting at 4 sites St. Justine's Hospital · San Diego, California and 8 other locations · NCT02434003

• Collection of data on orthopaedic conditions and rehabilitation

  This study collects information from patients with bone and muscle conditions at the University of Florida to help improve understanding and treatment of these issues.

  Recruiting University of Florida · Gainesville, Florida · NCT00411060

NIH-funded research (12)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• The RESILIENT Brace for teens with scoliosis

  A new flexible, adjustable scoliosis brace for adolescents to improve comfort, mobility, and real-time feedback to help keep curves from getting worse.

  NIH research Thinks Works, Pbc D/b/a Thinksworks · Austin, United States · NIH-11402856

• Developmental mechanisms behind adolescent idiopathic scoliosis

  A program of researchers is studying why scoliosis appears in some children and aims to uncover genetic and developmental clues that could lead to better understanding and future treatments.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11350943

• Understanding why adolescent scoliosis develops and how to prevent it

  A research collaboration is studying why adolescent idiopathic scoliosis (AIS) happens and how it progresses, with the goal of finding ways to prevent and better treat it for affected children.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11350942

• Low oxygen and mitochondria's role in spine development and congenital scoliosis

  This research looks at how low oxygen and mitochondrial changes during pregnancy can disrupt early spine formation and lead to congenital scoliosis.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11320814

• Understanding genetic causes of scoliosis

  This work looks at whether genes called ADGRG6 and SOX9 and their cell signals help keep the spine straight and could lead to ways to prevent or reduce scoliosis, especially in adolescents.

  NIH research University of Texas at Austin · Austin, United States · NIH-11257280

• Understanding the Causes of Adolescent Scoliosis

  This program aims to uncover the genetic and developmental reasons behind adolescent idiopathic scoliosis, a common spine condition in children.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11121810

• Understanding How Idiopathic Scoliosis Develops

  This research aims to uncover the root causes of adolescent idiopathic scoliosis, a spinal twisting condition affecting many children.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11121809

• Creating a tool to help make decisions about surgery for children with scoliosis

  This study is creating a helpful tool to support families in making better decisions about surgery for children with neuromuscular scoliosis, making sure that both doctors and families can work together during uncertain times.

  NIH research University of Utah · Salt Lake City, United States · NIH-11101102

• How low oxygen levels affect spine development and congenital scoliosis

  This study looks at how low oxygen levels during pregnancy might affect spine development and lead to scoliosis, using special mice to learn more about the underlying causes, which could help find new ways to treat these conditions in people.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11058501

• Understanding the cause of scoliosis in patients with neurofibromatosis type 1

  This study is looking into why some people with neurofibromatosis type 1 develop severe spinal curves, and it aims to find out how changes in certain cells during development affect the spine, which could help improve treatments for those dealing with this challenging condition.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11052559

• Evaluating physiotherapy for treating scoliosis in adolescents

  This study is looking at how a special type of exercise called the Schroth method can help teenagers with scoliosis by slowing down or preventing their spinal curve from getting worse, and it's designed just for young people dealing with this condition.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11013433

• Improving blood health in adolescents before scoliosis surgery

  This study is looking at how taking iron supplements before spinal fusion surgery can help teenagers with Adolescent Idiopathic Scoliosis feel better and recover faster, especially since many of them might be low on iron.

  NIH research Columbia University Health Sciences · New York, United States · NIH-10912801

Related topics

Quick answers

How many Scoliosis clinical trials are recruiting right now?

35, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 17 countries. The most sites are in United States (19 trials), France (6 trials), Canada (3 trials), Hong Kong (2 trials), Poland (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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