Condition

Degenerative Disc Disease clinical trials and research

• 25Clinical trials
• 1NIH research projects
• 13Countries

Newest Degenerative Disc Disease clinical trials

All recruiting trials (25)

• Bone marrow concentrate injection added to lumbar microdiscectomy

  This trial tests whether adding a bone marrow aspirate concentrate injection during lumbar microdiscectomy helps adults recover better than surgery alone.

  Recruiting Weill Medical College of Cornell University · Manhattan, New York · NCT07386548

• IDCT (Intradiscal Cell Therapy) for single-level mild-to-moderate lumbar degenerative disc disease

  This will test whether injecting IDCT (rebonuputemcel) into one degenerating lower-back disc can reduce chronic low back pain in adults with mild-to-moderate lumbar degenerative disc disease.

  Recruiting at 30 sites Phase 3 DiscGenics, Inc. · Birmingham, Alabama and 30 other locations · NCT07254806

• Novosis Putty used with transforaminal lumbar interbody fusion for lumbar degenerative disc disease

  The trial will test whether using Novosis Putty during transforaminal lumbar interbody fusion helps adults with lumbar degenerative disc disease heal better compared with standard care.

  Recruiting at 8 sites Phase 3 CGBio Inc. · Little Rock, Arkansas and 9 other locations · NCT07017634

• Evaluating a new treatment for painful disc degeneration

  This study is testing a new non-surgical treatment for people with painful disc degeneration to see if it can help relieve their back pain when other treatments haven't worked.

  Recruiting at 19 sites VIVEX Biologics, Inc. · Napa, California and 18 other locations · NCT06778447

• Evaluating a hybrid surgical approach for cervical degenerative disc disease

  This study is testing a new combined surgery for people with neck pain from two damaged discs to see if it works better and is safer than traditional surgery.

  Recruiting at 2 sites Highridge Medical · Sacramento, California and 1 other locations · NCT06485206

• Evaluating LDGraft for lumbar spine surgery

  This study is testing a new device called LDGraft to see if it is safe and effective for patients having surgery for lower back problems compared to using human tissue.

  Recruiting at 4 sites Phase 1/2 Locate Bio Ltd · Fort Wayne, Indiana and 3 other locations · NCT06462729

• New treatment for neuropathic pain in spinal cord injury patients

  This study is testing a new oral medication called EC5026 to see if it can safely help people with spinal cord injuries manage their nerve pain.

  Recruiting Phase 1 EicOsis Human Health Inc. · Augusta, Georgia · NCT06438471

• Post-market follow-up on Stryker spinal devices used in cervical and thoracolumbar fusion for degenerative spine conditions

  This PMCF study tests how well and safely Stryker spinal devices perform over two years in adults undergoing cervical or thoracolumbar fusion for degenerative disc disease or degenerative scoliosis.

  Recruiting at 7 sites VB Spine, LLC · Jacksonville, Florida and 6 other locations · NCT06226272

• Evaluation of a Carbon Fiber Device for Spinal Surgery

  This study is testing a new carbon fiber device for spinal surgery to see if it works better than traditional titanium screws for patients with degenerative spinal diseases.

  Recruiting Istituto Ortopedico Rizzoli · Bologna · NCT06209684

• Comparing two types of artificial discs for neck surgery

  This study is testing two different artificial discs for neck surgery to see which one helps people with neck problems feel better and move more easily after surgery.

  Recruiting University of California, Los Angeles · Los Angeles, California · NCT05701059

• Minimally invasive artificial disc replacement for chronic low back pain

  This study is testing a new device for replacing damaged discs in the lower back to see if it can help people with chronic back pain feel better without the downsides of traditional surgery.

  Recruiting at 4 sites Spinal Stabilization Technologies · Medellín, Antioquia and 10 other locations · NCT05508360

• Registry for patients using OssDsign® bone grafts in spine fusion

  This study is tracking how well OssDsign® bone grafts work for people having spine fusion surgery to see if they help with recovery over two years.

  Recruiting at 8 sites OssDsign · Fresno, California and 15 other locations · NCT05329129

• Monitoring the safety and performance of Ennovate® Cervical implants

  This study is looking at how safe and effective the Ennovate® Cervical implants are for patients with different spinal problems like fractures and disc disease.

  Recruiting Aesculap AG · Hamburg, Free and Hanseatic City of Hamburg and 3 other locations · NCT05296889

• Treating Painful Degenerative Disc Disease with Platelet-Based Treatments

  This study is testing whether two new platelet-based treatments can help people with painful degenerative disc disease feel better compared to a placebo.

  Recruiting at 2 sites Regenexx, LLC · Broomfield, Colorado and 1 other locations · NCT05287867

• Comparing two bone grafts for spine surgery outcomes

  This study is testing whether two different bone grafts can help patients with spine surgery heal better and achieve solid bone fusion.

  Recruiting Lindenhofgruppe AG · Bern · NCT05238740

• Comparing two bone graft extenders for spinal fusion surgery

  This study is testing whether a new bone graft extender called MagnetOs Flex Matrix works better than Trinity Elite for helping patients with degenerative disc disease heal after spinal fusion surgery.

  Recruiting at 9 sites Kuros Biosurgery AG · Hartford, Connecticut and 8 other locations · NCT05037968

• Using regional anesthesia to reduce opioid use in spine surgery

  This study is testing if a special pain management technique can help people having spine surgery use less opioid medication after their operation.

  Recruiting Phase 4 Rush University Medical Center · Chicago, Illinois · NCT05029726

• Investigating how cannabis helps relieve pain

  This study is testing how vaporized cannabis helps relieve pain by looking at how it affects the brain while participants feel controlled heat.

  Recruiting Early Phase 1 University of California, San Diego · La Jolla, California · NCT04982965

• OssiMend BA for posterolateral instrumented lumbar fusion

  This trial will try OssiMend Bioactive Moldable as the bone graft in adults having instrumented posterolateral lumbar fusion for degenerative disc disease to see if the spine fuses by 12 months.

  Recruiting Collagen Matrix · Encinitas, California and 3 other locations · NCT04775537

• Follow-up on outcomes after surgery with the LISA implant for back pain

  This study looks at how well the LISA implant works and its safety for people who have had surgery for chronic low-back pain.

  Recruiting at 5 sites Backbone · Silkeborg and 4 other locations · NCT04631133

• Registry for patients with personalized spine rods

  This study is testing whether personalized spine rods can help patients who have had spinal surgery feel better and have fewer problems compared to those with standard rods.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT04601363

• Preventive treatment for adjacent segment issues after lumbar fusion surgery

  This study is testing whether a small surgery to relieve pressure on the spine can help prevent problems in nearby areas after people have lumbar fusion surgery.

  Recruiting Peking University Third Hospital · Beijing, Beijing Municipality · NCT04469387

• Impact of pre-existing degeneration on outcomes after lumbar fusion surgery

  This study looks at how existing back problems affect recovery and quality of life for patients undergoing lumbar fusion surgery.

  Recruiting Peking University Third Hospital · Beijing, Beijing Municipality · NCT04467944

• Comparing two methods for cervical spine surgery

  This study is testing whether using Tritanium C or structural allograft bone during cervical spine surgery leads to better healing and fewer problems for patients.

  Recruiting Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) · Pittsburgh, Pennsylvania · NCT04388332

• Evaluating a new bone graft for spine surgery

  This study is testing a new bone graft to see if it helps people with degenerative disc disease feel better after spine surgery.

  Recruiting at 2 sites Bone Biologics Corp · Clayton, Victoria and 1 other locations · NCT03810573

NIH-funded research (1)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Using modified stem cell particles to treat degenerative disc disease

  This study is exploring a new treatment for low back pain caused by degenerative disc disease, using tiny particles from specially modified stem cells to help reduce inflammation and promote healing in your discs, which could lead to less pain and better movement.

  NIH research Rochester Institute of Technology · Rochester, United States · NIH-10873279

Related topics

Quick answers

How many Degenerative Disc Disease clinical trials are recruiting right now?

25, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in United States (17 trials), China (2 trials), Australia (2 trials), Germany (2 trials), Switzerland (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 2, Phase 4: 1, Phase 1/2: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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