Developmental mechanisms behind adolescent idiopathic scoliosis
Official title: Developmental Mechanisms of Human Idiopathic Scoliosis
Funded at Ut Southwestern Medical Center · NIH-11350943 · Data updated 2026-11-12
A program of researchers is studying why scoliosis appears in some children and aims to uncover genetic and developmental clues that could lead to better understanding and future treatments.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 1, 2016 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $321,459 |
| NIH project number | 5P01HD084387-10 |
| Project ID | NIH-11350943 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children and adolescents with AIS or a family history of the condition could benefit from future discoveries and applications stemming from this program.
✕Less likely to help
This core administrative and discovery program does not directly enroll patients in this phase.
What this research studies
This program combines human gene discovery, zebrafish models, and genome analysis to uncover causes of adolescent idiopathic scoliosis. It brings together three research groups and an Administrative Core to coordinate data, compliance, and productivity. The effort may ultimately pave the way for better diagnosis and someday new interventions for AIS in affected youth. Participants are not specified here, but the work centers on understanding a condition that affects children and could influence future patient care.
Why it matters
Potential benefit: If successful, the project could lead to better understanding of AIS causes and inform future diagnostics or therapies for affected children.
How similar studies have gone: Related AIS genetic and developmental research has progressed in model systems and human studies, suggesting potential for meaningful insights.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Wise, Carol a — Ut Southwestern Medical Center
- Study coordinator: Wise, Carol a
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.