Evaluation of a new model to predict scoliosis progression in adolescents

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to refine a predictive model for the progression of adolescent idiopathic scoliosis (AIS) by analyzing 3D spinal parameters. The model, developed from a cohort of 195 patients, seeks to identify those at significant risk of curve progression, allowing for proactive management strategies such as brace treatment. By distinguishing between patients who will progress and those who will not, the study aims to optimize treatment approaches and reduce unnecessary interventions. The research will involve multiple centers and will include patients with specific eligibility criteria related to their scoliosis condition.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Idiopathic Scoliosis (as diagnosed by the surgeon)
* Patients above 10 year old at the time of recruitment
* Spina bifida occulta with no neurological signs and otherwise normal
* Curves ranging between 11º and 40º of Cobb angle measurement and
* Risser 0 or 1, as measured on a standing postero-anterior digital radiograph of the spine.
* All single thoracic, thoraco-lumbar, lumbar, double major and triple major curves will be included in the study.

Exclusion Criteria:

* Previous thoracic, pelvis or spine surgery as they may be co-factors in scoliosis initiation,
* Congenital scoliosis,
* MRI abnormalities (including \> 4mm of Syrinx and/or Chiari malformation)
* Syndromic scoliosis (associated with Marfan's or other genetic syndromes),
* Neuromuscular scoliosis,
* Developmental delay
* Spinal asymmetry
* Symptomatic spondylolisthesis
* Leg length discrepancy longer than 1 cm.
* Unable or unwilling to firmly commit to returning for required follow-up visits

Where it's running

• Rady Children's Hospital
  San Diego, California, United States Recruiting
• St Justine's Hospital
  Montreal, Quebec, Canada Recruiting
• Queen Mary Hospital
  Hong Kong, Hong Kong Recruiting
• The Meijo Hospital
  Nagoya, Japan Recruiting
• Alfred I. duPont Hospital for Children
  Wilmington, Delaware, United States Not yet recruiting
• Miami Children's Hospital
  Miami, Florida, United States Not yet recruiting

Study contacts

• Principal investigator: Stefan Parent, MD, PhD — St. Justine's Hospital
• Study coordinator: Stefan Parent, MD, PhD
• Email: stefan.parent@umontreal.ca

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.