Condition

Congenital Diaphragmatic Hernia clinical trials and research

• 26Clinical trials
• 11NIH research projects
• 6Countries

Newest Congenital Diaphragmatic Hernia clinical trials

All recruiting trials (26)

• Melatonin plus inhaled nitric oxide for pulmonary hypertension in full-term newborns

  This study tests whether adding melatonin to inhaled nitric oxide helps treat pulmonary hypertension in full-term neonates.

  Recruiting Ain Shams University · Cairo, Abbassia · NCT07850934

• FETO with a Goldballoon device for fetuses with diaphragmatic hernia

  This study tests whether performing Fetoscopic Endoluminal Tracheal Occlusion on pregnancies with fetal diaphragmatic hernia improves baby survival and reduces long-term problems.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT07577414

• Fetal tracheal occlusion (FETO) for severe congenital diaphragmatic hernia

  This trial will test whether fetal endoluminal tracheal occlusion (FETO) helps fetuses with severe congenital diaphragmatic hernia and intrathoracic liver herniation survive to hospital discharge.

  Recruiting Phase 3 Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT07187206

• Long-term outcomes after FETO for severe left or right congenital diaphragmatic hernia

  This trial will test whether performing FETO in fetuses with isolated severe left or right CDH helps more babies survive to hospital discharge and have fewer long-term problems than standard care.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT07166172

• Fetal treatment for congenital diaphragmatic hernia

  This study is testing a new way to treat congenital diaphragmatic hernia in unborn babies by placing a balloon in their airway to help their lungs grow before they are born.

  Recruiting Children's Hospital of Philadelphia · Philadelphia, Pennsylvania · NCT06884423

• Fetoscopic balloon (FETO) for severe left and right congenital diaphragmatic hernia — long-term outcomes

  This trial will try placing and later removing a tiny balloon in the fetal windpipe around 27–29 weeks to help babies with severe congenital diaphragmatic hernia and liver herniation survive the newborn period.

  Recruiting The University of Texas Health Science Center, Houston · Houston, Texas · NCT06739356

• Arginine and ADMA levels during recovery from neonatal abdominal surgery

  This will test whether blood levels of arginine and ADMA can help predict recovery and complications in babies born after 35 weeks who need abdominal surgery in the first five days of life.

  Recruiting at 2 sites Liverpool Women's NHS Foundation Trust · Liverpool, Merseyside and 1 other locations · NCT06731855

• Physiological umbilical cord clamping for newborns with congenital diaphragmatic hernia

  This study tests if a special way of clamping the umbilical cord can help newborns with congenital diaphragmatic hernia breathe better and have healthier hearts compared to the usual method.

  Recruiting Hospital JP Garrahan · Buenos Aires · NCT06408376

• Fetal tracheal balloon occlusion to boost lung growth in severe congenital diaphragmatic hernia

  This will try a fetoscopic tracheal balloon procedure to promote lung development in fetuses with severe left congenital diaphragmatic hernia.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT05962346

• Understanding how adolescents with repaired diaphragmatic hernia engage in sports and activities

  This study looks at how teens who had CDH surgery as babies try sports and physical activities, and what helps or hinders them.

  Recruiting University Hospital, Lille · Lille · NCT05666986

• Fetal endoscopic tracheal occlusion for severe congenital diaphragmatic hernia

  This study is testing if placing a balloon in the trachea of fetuses with severe congenital diaphragmatic hernia can help their lungs develop better.

  Recruiting Stanford University · Stanford, California · NCT05461222

• Fetoscopic procedure for severe congenital diaphragmatic hernia in fetuses

  This study is testing a new procedure that places a balloon in the trachea of unborn babies with severe congenital diaphragmatic hernia to see if it helps their lungs grow and improves their chances of survival after birth.

  Recruiting Ann & Robert H Lurie Children's Hospital of Chicago · Chicago, Illinois · NCT05450653

• Fetal treatment for severe congenital diaphragmatic hernia

  This study is testing a new procedure for pregnant women with severe congenital diaphragmatic hernia to see if it can help improve their baby's lung development before birth.

  Recruiting University of California, Davis · Sacramento, California · NCT05421676

• Stopping routine inhaled nitric oxide during newborn stabilization for congenital diaphragmatic hernia

  This study will test whether stopping inhaled nitric oxide during initial resuscitation helps newborns with CDH avoid extracorporeal life support (ECLS) or death.

  Recruiting at 19 sites Phase 4 The University of Texas Health Science Center, Houston · Birmingham, Alabama and 18 other locations · NCT05213676

• Using Sildenafil to Treat Neonates with Congenital Diaphragmatic Hernia

  This study is testing if sildenafil can help newborns with congenital diaphragmatic hernia and high blood pressure in their lungs recover better after surgery.

  Recruiting Phase 2 University of Utah · Salt Lake City, Utah · NCT05201144

• Assessing respiratory muscle function in children

  This study tests how strong the breathing muscles are in children with breathing problems to see if better treatments can help them breathe easier.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT05051254

• Comparing two types of ventilation for newborns with congenital diaphragmatic hernia

  This study is testing whether high frequency jet ventilation or high frequency oscillatory ventilation works better for newborns with congenital diaphragmatic hernia who need help breathing.

  Recruiting at 2 sites University of Utah · Salt Lake City, Utah and 1 other locations · NCT04774848

• Fetoscopic surgery to treat severe congenital diaphragmatic hernia in fetuses

  This study is testing a new prenatal surgery to see if it can help unborn babies with a serious lung condition called congenital diaphragmatic hernia grow their lungs better and survive after birth.

  Recruiting University of California, San Francisco · San Francisco, California · NCT04583644

• Investigating cord resuscitation techniques for newborns with congenital diaphragmatic hernia

  This study is testing if delaying the clamping of the umbilical cord can help full-term newborns with congenital diaphragmatic hernia breathe better and have better health outcomes.

  Recruiting at 3 sites University Hospital, Lille · Amiens and 2 other locations · NCT04429750

• Observational study on congenital diaphragmatic hernia in newborns and children

  This study looks at how congenital diaphragmatic hernia affects the heart and lungs in newborns and children to see if they face ongoing health challenges as they grow up.

  Recruiting McGill University Health Centre/Research Institute of the McGill University Health Centre · Montreal, Quebec · NCT04114578

• Fetal tracheal occlusion to improve lung development in fetuses with severe congenital diaphragmatic hernia

  This study is testing whether a procedure that temporarily blocks the trachea of fetuses with severe congenital diaphragmatic hernia can help their lungs develop better and improve their chances of survival at birth.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT03980717

• Using 3D models to help manage congenital diaphragmatic hernia in fetuses

  This study is trying to use 3D models made from MRI scans to help parents and doctors better understand and plan for surgery for fetuses with congenital diaphragmatic hernia.

  Recruiting Sheffield Teaching Hospitals NHS Foundation Trust · Sheffield, South Yorkshire · NCT03750266

• Fetal tracheal balloon procedure to help lungs grow in severe congenital diaphragmatic hernia

  This will try a temporary tracheal balloon (FETO) in pregnant women carrying a fetus with severe left or right congenital diaphragmatic hernia to see if it helps the lungs grow and is safe.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT03674372

• Fetoscopic tracheal balloon occlusion for severe left congenital diaphragmatic hernia

  This research will try placing a temporary balloon in the fetal windpipe to help lungs grow in pregnancies where the baby has a severe left congenital diaphragmatic hernia.

  Recruiting University of Miami · Miami, Florida and 1 other locations · NCT03138863

• Fetal tracheal occlusion for severe congenital diaphragmatic hernia

  This study is testing if a procedure called fetal tracheal occlusion can help improve lung development in unborn babies with severe congenital diaphragmatic hernia.

  Recruiting Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT02986087

• Identifying genes linked to congenital diaphragmatic hernia

  This study is trying to find out which genes are linked to congenital diaphragmatic hernia to help improve how we diagnose and treat this birth defect.

  Recruiting at 12 sites Columbia University · Chicago, Illinois and 13 other locations · NCT00950118

NIH-funded research (11)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Inhaled Nitric Oxide for Babies with CDH

  A multi-center study tests whether stopping routine use of inhaled nitric oxide in newborns with congenital diaphragmatic hernia is safe and effective so care can be simpler and potentially better.

  NIH research University of Tennessee Health Sci Ctr · Memphis, United States · NIH-11397198

• Fetal tracheal aspirates to guide CDH therapies and timing for lung growth

  A researcher is studying fetal tracheal samples from babies with congenital diaphragmatic hernia to figure out which treatments and timing could help their lungs grow better.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11374043

• Integrating growth models and preclinical data to improve CDH patch repair

  A study to help babies with congenital diaphragmatic hernia by improving how surgical patches interact with growing tissues.

  NIH research Georgia Institute of Technology · Atlanta, United States · NIH-11373946

• Extracellular vesicles to boost fetal lung vessels in babies with diaphragmatic hernia

  Aims to use tiny particles from stem cells to help growing lungs in babies with congenital diaphragmatic hernia before birth.

  NIH research Washington University · Saint Louis, United States · NIH-11345211

• Inhaled Nitric Oxide for CDH: A pragmatic, multi-center trial to guide care for newborns with congenital diaphragmatic hernia

  This trial tests whether stopping routine inhaled nitric oxide use after birth helps seriously ill newborns with congenital diaphragmatic hernia.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11261516

• Finding genes that cause congenital diaphragmatic hernia

  This project uses fast CRISPR gene-editing in mice to find which genetic changes are responsible for congenital diaphragmatic hernia in babies.

  NIH research Jackson Laboratory · Bar Harbor, United States · NIH-11187163

• Understanding lung development in babies with congenital diaphragmatic hernia

  This work aims to uncover why the lungs of babies with congenital diaphragmatic hernia do not develop properly.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11169895

• Using inhaled nitric oxide to treat congenital diaphragmatic hernia in newborns

  This study is looking at whether inhaled nitric oxide can help newborns with congenital diaphragmatic hernia during their critical early days after birth, and it aims to gather solid information to help doctors make better treatment decisions for these babies.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-10985924

• Using inhaled nitric oxide to treat congenital diaphragmatic hernia in newborns

  This study is looking at how well inhaled nitric oxide helps newborns with congenital diaphragmatic hernia, a condition that affects their lungs, to see if it can improve their health and make a difference in their treatment.

  NIH research University of Tennessee Health Sci Ctr · Memphis, United States · NIH-10985923

• Identifying and validating new genetic variants linked to congenital diaphragmatic hernia

  This study is looking at congenital diaphragmatic hernia (CDH), a birth defect that can cause breathing problems in babies, and it aims to find new genetic clues that could help us understand and treat this condition better, using special technology to test these clues in mice.

  NIH research Jackson Laboratory · Bar Harbor, United States · NIH-10942353

• Using biodegradable patches to treat congenital diaphragmatic hernia

  This study is testing new stretchy patches made from biodegradable materials to help treat congenital diaphragmatic hernia in babies, aiming to improve healing and reduce complications as the child grows.

  NIH research University of Texas Arlington · Arlington, United States · NIH-10667413

Related topics

Quick answers

How many Congenital Diaphragmatic Hernia clinical trials are recruiting right now?

26, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (18 trials), France (3 trials), Egypt (2 trials), United Kingdom (2 trials), Argentina (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1, Phase 3: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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