Understanding the Causes of Adolescent Scoliosis
Developmental Mechanisms of Human Idiopathic Scoliosis
['FUNDING_P01'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-11121810
This program aims to uncover the genetic and developmental reasons behind adolescent idiopathic scoliosis, a common spine condition in children.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-11121810 on ClinicalTrials.gov |
What this research studies
We are exploring why adolescent idiopathic scoliosis, a common spine curvature in children, develops. Our approach involves looking for new genes in people with scoliosis and studying how these genes work in zebrafish models. We also examine how genes are controlled in the body to better understand the root causes of this condition. This combined effort helps us piece together the complex puzzle of scoliosis development.
Who could benefit from this research
Good fit: This research focuses on children and adolescents affected by idiopathic scoliosis, particularly those who might contribute genetic information or samples.
Not a fit: Patients whose scoliosis is not idiopathic (meaning it has a known cause) or adults with scoliosis may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of scoliosis, potentially paving the way for earlier detection or new treatment strategies.
How similar studies have performed: While gene discovery in complex conditions is ongoing, this program combines established methods in human genetics and model organisms to identify underlying causes.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WISE, CAROL A — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: WISE, CAROL A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.