Testing new treatments for Progressive Supranuclear Palsy.
Official title: The Progressive Supranuclear Palsy Clinical Trial Platform (PTP)
Funded at University of California, San Francisco · NIH-10784249 · Data updated 2026-11-12
This study is creating a new way to test different treatments for Progressive Supranuclear Palsy (PSP) to see how safe and effective they are, and it’s for people living with PSP who want to help find better therapies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $15,782,145 |
| NIH project number | 1R01AG085029-01 |
| Project ID | NIH-10784249 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are individuals diagnosed with mild to moderate Progressive Supranuclear Palsy.
✕Less likely to help
Patients with advanced stages of Progressive Supranuclear Palsy or those with other unrelated neurodegenerative diseases may not benefit from this research.
What this research studies
This research aims to develop a clinical trial platform specifically for Progressive Supranuclear Palsy (PSP), a severe neurodegenerative disease. The study will evaluate the safety and effectiveness of multiple therapies simultaneously, including those being tested for Alzheimer's and amyotrophic lateral sclerosis. Patients will be monitored using a specialized rating scale to assess their condition over a 12-month period. The goal is to streamline the process of testing new treatments and to identify effective therapies more quickly.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients suffering from Progressive Supranuclear Palsy.
How similar studies have gone: Previous research has shown promise in using platform trials for other neurodegenerative diseases, indicating potential success for this approach in PSP.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Boxer, Adam L. — University of California, San Francisco
- Study coordinator: Boxer, Adam L.
Related research
Other NIH-funded projects on the same topics.
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Imaging brain changes over time in progressive supranuclear palsy
This project uses repeated brain scans to track disease-related changes over time in people with progressive supranuclear palsy.
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Tau’s effect on protein production in Alzheimer’s and PSP
This grant investigates how abnormal tau protein disrupts the way cells make proteins, which may contribute to memory problems in Alzheimer’s disease and PSP.
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Platform to try new treatments for progressive supranuclear palsy
This project will compare three medicines for people with mild to moderate progressive supranuclear palsy to learn if they are safe and help symptoms.
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Investigating tau protein accumulation and its effects on movement in brain injuries.
This study is looking at how repeated head injuries might lead to movement problems, like those seen in Parkinson's disease, by examining changes in the brain after someone has passed away, and it aims to find clues that could help diagnose these issues better for people affected by chronic traumatic encephalopathy (CT
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Using brain stimulation to improve balance in patients with progressive supranuclear palsy
This study is looking at a safe and painless way to use brain stimulation to help people with progressive supranuclear palsy (PSP) improve their balance and reduce the risk of falling, so they can stay active and independent for longer.
-
Understanding walking and balance problems in a rare neurological condition.
This study is looking at how walking and balance problems affect people with progressive supranuclear palsy (PSP) and aims to create better ways to measure these issues so that patients can receive improved care and support.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.