A new zebrafish model to study balance issues in progressive supranuclear palsy

Who could benefit from this research

What this research studies

This research investigates progressive supranuclear palsy (PSP), a neurodegenerative disease that causes severe balance problems and other neurological symptoms. The team is developing a zebrafish model that mimics the Tau protein pathology associated with PSP, allowing for better understanding and evaluation of potential treatments. By using zebrafish, which are small and have easily observable behaviors, researchers aim to link the underlying biological mechanisms of balance deficits to the symptoms experienced by patients. The model will be validated through various neurological and behavioral tests to ensure its relevance to human PSP.

Why it matters

Where this research is happening

• New York University School of Medicine
  New York, United States Active

Researchers

• Principal investigator: Schoppik, David — New York University School of Medicine
• Study coordinator: Schoppik, David

Related research

Other NIH-funded projects on the same topics.

• Imaging brain changes over time in progressive supranuclear palsy

  This project uses repeated brain scans to track disease-related changes over time in people with progressive supranuclear palsy.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11299639

• Tau’s effect on protein production in Alzheimer’s and PSP

  This grant investigates how abnormal tau protein disrupts the way cells make proteins, which may contribute to memory problems in Alzheimer’s disease and PSP.

  NIH research University of Florida · Gainesville, United States · NIH-11215570

• Platform to try new treatments for progressive supranuclear palsy

  This project will compare three medicines for people with mild to moderate progressive supranuclear palsy to learn if they are safe and help symptoms.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11160498

• Investigating tau protein accumulation and its effects on movement in brain injuries.

  This study is looking at how repeated head injuries might lead to movement problems, like those seen in Parkinson's disease, by examining changes in the brain after someone has passed away, and it aims to find clues that could help diagnose these issues better for people affected by chronic traumatic encephalopathy (CT

  NIH research Boston University Medical Campus · Boston, United States · NIH-11085161

• Using brain stimulation to improve balance in patients with progressive supranuclear palsy

  This study is looking at a safe and painless way to use brain stimulation to help people with progressive supranuclear palsy (PSP) improve their balance and reduce the risk of falling, so they can stay active and independent for longer.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11074107

• Understanding walking and balance problems in a rare neurological condition.

  This study is looking at how walking and balance problems affect people with progressive supranuclear palsy (PSP) and aims to create better ways to measure these issues so that patients can receive improved care and support.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-10912445

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.