Using noninvasive brain stimulation to improve language function in patients with primary progressive aphasia
Treating primary progressive aphasia and elucidating neurodegeneration in the language network using transcranial direct current stimulation
This study is exploring how a gentle brain stimulation technique called tDCS can help people with primary progressive aphasia, a condition that affects language skills in those with Alzheimer's or frontotemporal dementia, by boosting their brain's ability to communicate better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10670952 on NIH RePORTER |
What this research studies
This research investigates the use of transcranial direct current stimulation (tDCS) to treat primary progressive aphasia (PPA), a condition that causes language loss in patients with Alzheimer's disease and frontotemporal dementia. The study aims to understand how tDCS can enhance the brain's language network by either strengthening weakened connections or supporting compensatory mechanisms in healthier areas. Participants will undergo a randomized, sham-controlled crossover trial to evaluate the effectiveness of this noninvasive neuromodulation technique. By focusing on specific regions of the brain, the research seeks to identify the most effective treatment strategies for improving language abilities in individuals with PPA.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with primary progressive aphasia, particularly those with variants associated with Alzheimer's disease or frontotemporal dementia.
Not a fit: Patients who do not have primary progressive aphasia or those with other forms of dementia unrelated to language impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that significantly improve communication abilities for patients suffering from primary progressive aphasia.
How similar studies have performed: Previous research has shown promise for tDCS in enhancing cognitive functions, but this specific application for primary progressive aphasia is relatively novel.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Hamilton, Roy H — University of Pennsylvania
- Study coordinator: Hamilton, Roy H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.