Understanding brain changes in a type of aphasia
Longitudinal multi-modality imaging in non-fluent/agrammatic primary progressive aphasia
This project looks at brain changes over time in people with a specific type of language disorder called non-fluent/agrammatic primary progressive aphasia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11137609 on NIH RePORTER |
What this research studies
This project aims to understand how brain changes, like inflammation and protein buildup, contribute to a language disorder called non-fluent/agrammatic primary progressive aphasia (nfvPPA). Researchers are using advanced brain scans, called PET imaging, to see patterns of inflammation in the brain. They are also studying blood samples to find specific markers that might show what's happening in the brain. By following these changes over time, we hope to learn more about how nfvPPA progresses and affects language abilities.
Who could benefit from this research
Good fit: Ideal candidates would be individuals diagnosed with non-fluent/agrammatic primary progressive aphasia who are willing to participate in long-term imaging and blood sample collection.
Not a fit: Patients without non-fluent/agrammatic primary progressive aphasia or those unable to undergo imaging or provide blood samples may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of non-fluent/agrammatic primary progressive aphasia, potentially helping to identify new ways to diagnose or track the disease.
How similar studies have performed: Previous cycles of this grant have successfully characterized neurodegeneration and tau deposition in nfvPPA, indicating a foundation for this continued work.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Whitwell, Jennifer Louise — Mayo Clinic Rochester
- Study coordinator: Whitwell, Jennifer Louise
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.